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What is penicillin class?
What does penicillin cover?
often gram +
What is the spectrum of Augmentin? (a penicillin)
- Gram +
- Some gram -
- Anaerobes like bacteroids
What is augmenting the drug of choice for?
Animal bites (pasturella multocida)
Augmentin is a great 1st line of defense against what?
- Mild Diabetic foot infections
What is Unasyn (a penicillin-- ampicillin/sulbactam) the drug of choice for?
presume aerobi and anaerobic infections
What is the spectrum fro Zosyn?
- Gram +
- Increased gram- coverage
What is the most common broad spectrum IV drug used in diabetic infections today?
Zosyn ( Pipercillin/Tazobactam)
What is the spectrum of Penicillin G?
- Pure streptococcal infections
- anaerobes including clostridia (no bactericidal coverage)
What is Penicillin G used to treat?
- open farm/soil injuries
- drug addition
What class are cephalosporins?
Beta lactamase inhibitors through PCN binding protein
What is an important fact about cephalosporins in relation to patient allergies?
10 % if patients with allergic hypersensitivity to PNC also have cx-rxn with cephalosporins
What is the spectrum for cephalosporins?
- Gram -
- anaerobes other than bacteroides
What gram negatives are treated with cephalosporins? (4)
- E. Coli
- P. mirabilis
What is Keflex (Cephalexin) used to treat as a 1st line of defense?
- Superficial infections in healthy patients
- Ex: cellulitis, ingrown nails
Great Bone penetration with long half life (surgical prophylaxis)
What are aminoglycosides?
- protein synthesis inhibitors
- bind to 30s and 50 s ribosomal subunit
- administered IV or IM only
What are adverse effects of amino glycosides?
What is the spectrum of gentamicin? (amino glycoside)
- Aeorbic gram negatives
- NO ANAEROBIC COVERAGE
When does gentamycin peak/tough?
- peak= following administration
- trough= 20-30 mins prior to nect does
What do you monitor with gentamycin?
What does clindamycin do?
inhibit protein biosynthesis via 50s ribosome
What is the spectrum of Clindamycin?
Does Clindamycin cover C. diff?
Describe the metabolism of Clinamycin
- By the liver
- good agisnt some strains of MRSA
What is an adverse effect of clindamycin?
What is Clindamycin prescribed for?
open fractures only with a PCN allergy
What is the spectrum fro Vancomycin?
- ALL GRAM +
- gram + anaerobes like clostridia, corynebacteria
- NO gram -
What is an adverse effect go Vancomycin?
- Red Man syndrome
When can oral vancomycin be given?
ONLY for pseudomembranous colitis after flagyl fails
What is Vancomycin used in conjunction with? for what?
with Zosyn for IV Abx coverage in diabetic infections for coverage of MRSA
What is the spectrum of Zyvox?
- ALL GRAM +
- including ENTEROCOCCUS and MRSA
what is the bioavailibility of Zyvox and why does that matter?
100% bioavailble = only IV for those who cannot tolerate PO
Adverse effects of Zyvix (5)
- Peripheral neuropathy (only in prolonged >3mo use)