KIDNEY

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Author:
mayo0osh
ID:
248768
Filename:
KIDNEY
Updated:
2013-11-24 07:25:20
Tags:
normal values
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Description:
physiology
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  1. GFR
    120-125 ml/min
  2. RPF
    • 660 ML/MIN
    • PAH-clearance=RPF
  3. FF = FILTRATION FRACTION
    0.2
  4. autoregulation range:
    80-180 mmHg
  5. RBF
    1320 ml/min

    RBF is 20-23% of resting cardiac output,

    normalized renal blood flow 420 ml/min/100g (cardiac muscle 84,brain 54 , skeletal muscle 2.7 ml/min/100 g)
  6. inulin clearance
    GFR
  7. 1.PLASMA CREATININE
    2.CREATININE CLEARANCE
    • 1)50-150 μM,
    • 2)90-150 ml/min
  8. renal threshold of glucose
    10 mM,
  9. plasma uric acid
    : 150-500 μM
  10. 1.maximal osmotic concentration the outer medulla (short-loop nephron):

    2.in the inner medulla (long-loop nephron):

    3.max. urea concentration in inner medulla
    • 1) 600 MOSMOL/LITER
    • 2) 1200 mosmol/liter
    • 3) 600 mosmol/liter
  11. urine osmotic concentration

    urine specific gravity

    diuresis and its interpretation:
    : anuria, oliguria, polyuria,

    in diabetes insipidus can reach 18-25 l/day!;

    minimal daily excreted osmotic activity
    urine osmotic concentration: 70-1200 mosmol/L

    urine specific gravity: 1001-1030 g/l (blood plasma 1012 g/l)

    • diuresis and its interpretation:<100 ml/day: anuria;100-600 ml/day:
    • oliguria, 600-2500 ml/day:
    • normal range, >2500 ml/day:
    • polyuria,

    in diabetes insipidus can reach 18-25 l/day!;

    minimal daily excreted osmotic activity: 650 mosmol.
  12. Na+ dietary intake/loss
    100-400 mmol/day

    this corresponds with ~5-30g table salt consumption.
  13. K+-intake/loss
    50-100 mmol/day
  14. Ca2+ intake/absorption
    Ca2+ loss
    vitamin D RDA
    Ca2+ intake/absorption 1000/200 mg/day ,also 25/5 mmol/day

    Ca2+ loss: 2,5-7,5 mmol/day,

    vitamin D RDA: 600 IU/day (between 1-70 years of age)
  15. arterial blood PH

    Standard bicarbonate

    buffer base
    base excess

    acid production

    urine PH
    arterial blood pH: 7,37-7,43

    standard bicarbonate: 24 mmol/L,

    • buffer base (BB): 44-49 mmol/L
    • base excess (BE): +2,5– -2,5 mmol/L,
    • anion gap: 8-12 mmol/l;

    acid productions (nonvolatile)): 50-100 mmol/day,

    • urine pH: 4.0-8.0;
    • tubular bicarbonate „ reabsorption”: 4300 mmol/day,
    • new bicarbonate production: 50-100 mmol/day

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