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The flashcards below were created by user
kyleannkelsey
on FreezingBlue Flashcards.
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What type of filter would be used for intermittent Hemodialysis?
High-Fluc dialysis filter or conventional filter
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What does CAVHDF or CVVHDF stand for?
Continuous arteriovenous or venovenous hemodiafiltration
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What does CAVH or CVVH stand for?
Continuous arteriovenous or vevovenous hemofiltration
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What are the Continuous Renal Replacement Thereapies?
CAVHDF/CVVHDF or CAVH/CVVH
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How is IPD achieved?
The patient’s own peritoneal fluids are used to remove electrolytes and toxins
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What is the least likely method of Hemodialysis to remove drugs?
IPD
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Would a CRRT method or an intermittent hemodialysis method be set at a higher rate?
Intermittent
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CRRT or IHD remove more medication?
CRRT
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Between the various Hemodiualysis methods, rank them in order of most and least likely to remove mediactions:
CAVHDF/CVVHDF > CAVH/CVVH > High Flux Filter HD >Conventional Filter HD > IPD > CAPD
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A conventional filter hemodialysis can remove drugs with what molecular weight?
<1000 daltons
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A High-Flux filter hemodialysis can remove drugs with what molecular weight?
>1,000 – 20,000 daltons
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A Continuous Renal Replacement Therapies can remove drugs with what molecular weight?
>5,000 daltons
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Would Vancomycin be removed by a Conventional Filter Hemodialysis system, explain?
No, Vancomycin = 1,500 daltons, Conventional filter only removes <1,000 daltons
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Would Vancomycin be removed by a High-Flux Filter Hemodialysis system, explain?
Yes, Vancomycin = 1,500 daltons, High-Flux Filter Hemodialysis removes >1,000 – 20,000 daltons
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Would Aminoglycosides be removed by a Conventional Filter Hemodialysis system, explain?
Yes, Aminoglycosides = 500 daltons, Conventional filter removes <1,000 daltons
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What advantage does a Dialysis membrane with a higher ultrafiltration coefficient (Kuf) have?
Potential to remove more unbound drug
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What are the major variables of a Dialysis membrane?
Pore size and Ultrafiltration coefficient (Kuf)
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(True/False) Dialysate and Blood in a Dialysis machine flow in the same direction.
False, opposite directions
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What does QB stand for?
Blood flow
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What does QD or DFR stand for?
Dialysate Flow
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The faster the QB, the __________ the drug accumulates in the Dialysate.
Faster
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The faster the QD, the__________ the drug is removed from the dialyzer.
Faster
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What biomarkers can be used to quantify Renal plasma/blood flow?
PAH, 131 I-OIH and [99m]c-MAG3
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What biomarkers can be used to quantify Glomerular filtration rate?
Inulin, Sinstrin, lothalamate, 125I-lothalamate, lohexol, Creatine, Cystatin C, [99m]c-DTPA
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What biomarkers can be used to quantify Tubular function?
PAH, TEA, B2 or A1 microglobulin, RBP, Protein HC, NAG, AAP, ABP
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What is the most commonly used biomarker for Glomerular filtration rate?
Creatinine clearance
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Why is Creatinine clearance used preferentially over other biomarker methods?
It is less labor intensive or expensive
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Define Glomerular Filtration Rate:
Volume of fluid filtered through the glomerular capillaries into the Bowman’s capsule per unit time
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Define the Creatinine Clearance rate:
Volume of blood plasma that is cleared of creatinine per unit time
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