Pharmacokinetics Final Exam 3

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kyleannkelsey
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248846
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Pharmacokinetics Final Exam 3
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2013-11-24 17:58:00
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Pharmacokinetics Final Exam
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Pharmacokinetics Final Exam 3
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  1. What type of filter would be used for intermittent Hemodialysis?
    High-Fluc dialysis filter or conventional filter
  2. What does CAVHDF or CVVHDF stand for?
    Continuous arteriovenous or venovenous hemodiafiltration
  3. What does CAVH or CVVH stand for?
    Continuous arteriovenous or vevovenous hemofiltration
  4. What are the Continuous Renal Replacement Thereapies?
    CAVHDF/CVVHDF or CAVH/CVVH
  5. How is IPD achieved?
    The patient’s own peritoneal fluids are used to remove electrolytes and toxins
  6. What is the least likely method of Hemodialysis to remove drugs?
    IPD
  7. Would a CRRT method or an intermittent hemodialysis method be set at a higher rate?
    Intermittent
  8. CRRT or IHD remove more medication?
    CRRT
  9. Between the various Hemodiualysis methods, rank them in order of most and least likely to remove mediactions:
    CAVHDF/CVVHDF > CAVH/CVVH > High Flux Filter HD >Conventional Filter HD > IPD > CAPD
  10. A conventional filter hemodialysis can remove drugs with what molecular weight?
    <1000 daltons
  11. A High-Flux filter hemodialysis can remove drugs with what molecular weight?
    >1,000 – 20,000 daltons
  12. A Continuous Renal Replacement Therapies can remove drugs with what molecular weight?
    >5,000 daltons
  13. Would Vancomycin be removed by a Conventional Filter Hemodialysis system, explain?
    No, Vancomycin = 1,500 daltons, Conventional filter only removes <1,000 daltons
  14. Would Vancomycin be removed by a High-Flux Filter Hemodialysis system, explain?
    Yes, Vancomycin = 1,500 daltons, High-Flux Filter Hemodialysis removes >1,000 – 20,000 daltons
  15. Would Aminoglycosides be removed by a Conventional Filter Hemodialysis system, explain?
    Yes, Aminoglycosides = 500 daltons, Conventional filter removes <1,000 daltons
  16. What advantage does a Dialysis membrane with a higher ultrafiltration coefficient (Kuf) have?
    Potential to remove more unbound drug
  17. What are the major variables of a Dialysis membrane?
    Pore size and Ultrafiltration coefficient (Kuf)
  18. (True/False) Dialysate and Blood in a Dialysis machine flow in the same direction.
    False, opposite directions
  19. What does QB stand for?
    Blood flow
  20. What does QD or DFR stand for?
    Dialysate Flow
  21. The faster the QB, the __________ the drug accumulates in the Dialysate.
    Faster
  22. The faster the QD, the__________ the drug is removed from the dialyzer.
    Faster
  23. What biomarkers can be used to quantify Renal plasma/blood flow?
    PAH, 131 I-OIH and [99m]c-MAG3
  24. What biomarkers can be used to quantify Glomerular filtration rate?
    Inulin, Sinstrin, lothalamate, 125I-lothalamate, lohexol, Creatine, Cystatin C, [99m]c-DTPA
  25. What biomarkers can be used to quantify Tubular function?
    PAH, TEA, B2 or A1 microglobulin, RBP, Protein HC, NAG, AAP, ABP
  26. What is the most commonly used biomarker for Glomerular filtration rate?
    Creatinine clearance
  27. Why is Creatinine clearance used preferentially over other biomarker methods?
    It is less labor intensive or expensive
  28. Define Glomerular Filtration Rate:
    Volume of fluid filtered through the glomerular capillaries into the Bowman’s capsule per unit time
  29. Define the Creatinine Clearance rate:
    Volume of blood plasma that is cleared of creatinine per unit time

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