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What are the drugs associated with oxidative hemolysis (7 drugs mentioned in the class and 4 for self notes)
- Mentioned in class:
- Ascorbic acid- wk
- Chloramphenicol(Chloromycetin)
- Phynazopyridine (pyridium)- strong;
- Nitrofurantoin- mixed
- NSAIDS/ Aspirin - wk
- Co-trimoxazole (Bactrim)- strong
- Fava beans
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- self : dapsone, dimercaprol, methylene blue, premaquine
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Abciximab
- monoclonal antibody used after PCI, ACS
- cause immune mediated thrombocytopenia (antibody related)
- very rapid, absolute profound (10-20k )quick (w/t 24 hours) platelet decrease
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B-lactams
Thrombocytopenia (drug attach to platelet), neutropenia(WBC), hemolytic anemia (attach to RBC)Gell coombs type 2 ; IgG; cytotoxic rxn
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Quinidine/ Quinine(qualaquin)
- antiarrythmic Ia/ antimalarial
- - immune mediated thrombocytopenia
- ex) tonic water (quinine contain)- nondrug source of thrombocytopenia
- immune complex (innocent bystander) hemolytic anemia (IgG, IgM, rapid, profound)
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Linezolid (brand?)
- - Zyvox; G (+) resistance (VRE, MRSA,etc)
- - Thrombocytopenia- platelet count monitoring required!!(full actue myelosupression including platelet, RBC, granulocyte all affected)
- - occur 7-10days (when you wanna to CBC monitoring!
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