Pharmacology Bronchodilators 2

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kyleannkelsey
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248902
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Pharmacology Bronchodilators 2
Updated:
2013-11-24 21:55:38
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Pharmacology Bronchodilators
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Pharmacology Bronchodilators 2
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  1. What are oral preparations of Steroid anti-inflammatories used to treat?
    Severe persistent asthma
  2. What are the negative effects of Steroid anti-inflammatories?
    Oral candidiasis, possible bone reabsorption, adrenal suppression and metabolism and growth retardation
  3. What are the negative effects associated with oral steroid anti-inflammatory treatments?
    Adrenal suppression and metabolism and growth retardation
  4. What are the negative effects associated with inhalation steroid anti-inflammatory treatments?
    Oral candidiasis and possible bone reabsorption
  5. What is the MOA for Steroid anti-inflammatory drugs as prophylactic asthma drugs?
    Inhibits PLA2, ↓ Arachadonic acid, ↓ gene-expression of inflammatory mediators
  6. What are the two general treatment types for preventing recurrent episodes of asthma?
    1.) Steroid anti-inflammatories 2.) Inhibitors of mast cell and eosinophil mediator secretion 3.) Leukotriene modifiers 4.) Long acting 2 agonists 5.) Adenosine Receptor Blockers
  7. What drugs are inhibitors of mast cell and eosinophil mediator secretion?
    Cromolyn and Nedocromil
  8. What is the onset of action for Cromolyn and Nedocromil?
    Several Weeks
  9. What are Cromolyn and Nedocromil used to treat?
    Mild persistent asthma, allergic rhinitis and pollutant/exercise induced bronchospasm
  10. Inhibitors of mast cell and eosinophil mediator secretion (Cromolyn and Nedocromil) have what adverse effects?
    Mild irritation of the respiratory tract
  11. What are the Leukotriene Modifiers?
    Ziluton, Zafirlukast and Montelukast
  12. What is the MOA for Zileuton?
    Inhibits 5-ipoxygenase
  13. What is the MOA for Zafirlukast and Montelukast?
    Blcoks LTD-4 receptors
  14. What type of Leukotriene modifier is most useful for children?
    Oral
  15. What group are Leukotriene modifiers particularly effective in?
    The 10% of asthmatics who as aspirin sensitive
  16. (True/False) Clinical data clearly shows that Leukotriene Modifier are efficacious in long-term care of asthma.
    False, more clinical data needed
  17. What is the MOA of theophylline and Aminophylline?
    Block adenosine receptors of bronchial smooth muscle (inhibit PDE, casing increased cAMP)
  18. What are Theophylline/Aminophylline used for?
  19. Long term control of mild to moderate persistent asthma
  20. _______________ are adjuvants to steroids for nocturnal symptoms.
    Theophylline and Aminophylline
  21. By what route of administration are Theophylline and Aminophylline given?
    Oral
  22. What are the adverse effects of Theophylline and Aminophylline?
    N and V, Arrhythmias, CNS stimulations (nervousness/anxiety)
  23. (True/False) Theophylline and Aminophylline are preferred over Long acting B2 agonists?
    False
  24. What are the long acting B2 agonists?
    Salmeterol and Sustained release Albuterol
  25. Sustained release albuterol comes in what dosage form?
    Tablet
  26. Salmeterol is administered by what route?
    Inhaled
  27. Are Long acting B2 agonists used for reversal of acute attacks, if so, in what situations?
    Not used

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