Pharmacology Antihypertensives 1

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kyleannkelsey
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248904
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Pharmacology Antihypertensives 1
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2013-11-24 21:58:39
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Pharmacology Antihypertensives
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Pharmacology Antihypertensives 1
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  1. What is JNC VII?
    Joint national committee on prevention, detection, evaluation and treatment of high blood pressure
  2. What is Hypertension?
    Elevation of arterial blood pressure over 140/90 mm Hg
  3. What percent of Hypertension is due to underlying disease/secondary?
    10%
  4. What percent of Hypertension is idiopathic/Primary?
    90%
  5. What is acute hypertension?
    >120 mm Hg diastolic
  6. What are the major diseases that can be prevented by treating Hypertension?
    Stroke, CHF, CAD, Nephropathy, PAD, Retinopathy
  7. What systems control blood pressure?
    Sympathetic NS and Renin/Angiotensin/Aldosterone system
  8. What organs control blood pressure?
    Heart, Blood vessels and Kidney
  9. Finish the equation: MAP=
    CO x PVR
  10. What are each of the terms in the following equation: MAP = CO x PVR?
    Mean arterial Pressure = Cardiac output x Peripheral vascular resistance
  11. What drugs treat hypertension by reducing cardiac output?
    Beta-Blockers
  12. What general group of drugs treat hypertension by reducing peripheral vascular resistance?
    Vasodilators
  13. What group of drugs treat Hypertension by reducing plasma volume?
    Diuretics
  14. What are the peripheral acting sympatholytics used to treat hypertension?
    Beta –adrenergic receptor blockers and Alpha 1 – adrenergic receptor blockers
  15. What are the centrally acting sympatholytics used to treat hypertension?
    Alpha2- adrenergic receptor agonists
  16. What are the Renin Angiotensin System Blockers used to treat hypertension?
    Angiotensin converting enzyme inhibitors, Angiotensin II receptor blockers and Renin inhibitors
  17. What are the general types of drugs that can be used to treat Hypertension?
    Diuretics, Peripheral acting sympatholytics, centrally acting sympatholytics, Other sympatholytics, Renin Angiotensin System blockers, Calcium channel blockers, Direct vasodilators
  18. What is the site of action for Valsartan and other angiotensin receptor blockers?
    Angiotensin II receptors of vessels
  19. What is the site of action for Prazosin and other alpha-receptor blockers?
    Alpha-receptors of the vessels
  20. What is the site of action for Thiazides?
    Early Distal Convoluted Tubule
  21. What is the site of action for atenolol, Propranolol and other beta-blockers?
    Beta-receptors of juxtaglomerular cells that release renin
  22. What is the site of action for Respirine?
    Sympathetic nerve terminals
  23. What is the site of action for Methyldopa, Clonidine and Guafacine?
    Vasomotor center
  24. What is the site of action for Hydralazine?
    Vascular smooth muscle
  25. What is the site of action for Minoxidil?
    Vascular smooth muscle
  26. What is the site of action for Nitroprusside?
    Vascular smooth muscle
  27. What is the site of action for Diazoxide?
    Vascular smooth muscle
  28. What is the site of action for Calcium Channel Blockers?
    Vascular smooth muscle
  29. What is the site of action for Verapamil?
    Vascular smooth muscle
  30. What is the site of action for Diltiazam?
    Vascular smooth muscle
  31. What is the site of action for Amlopidine?
    Vascular smooth muscle
  32. What is the site of action for Fenoldopam?
    Vascular smooth muscle
  33. What is the site of action for Lisinopril and other ACE inhibitors?
    Angiotensin converting enzyme
  34. What is the action of Angiotensin converting enzyme?
    Converts Angiotensin I to Angiotensin II
  35. What is the action of Renin?
    Converts Angiotensinogen to Angiotensin I
  36. What is the site of action or Aliskiren?
    Renin
  37. Where is the site of action for Furosemide?
    Thick segmented ascending limb of Loop of Henle
  38. What is the site of action of Spirolactone and Triamterene?
    Late Distal Convoluted Tubule and Collecting duct
  39. What is the first treatment used for Hypertension?
    Lifestyle Modifications

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