Pharmacology Antihypertensives 4

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kyleannkelsey
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248907
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Pharmacology Antihypertensives 4
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2013-11-24 22:01:14
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Pharmacology Antihypertensives
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Pharmacology Antihypertensives 4
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  1. What group of patients are ACE inhibitors the drug of choice for and why?
    DM, reduces nephropathy
  2. What group of patients are ACE inhibitors a particularly good choice for?
    DM, CHF, LVH, Arrhythmias, asthmatics
  3. The efficacy of ACE inhibitors can be increased by combining them with what other drug?
    Diuretics
  4. ACE inhibitors have what adverse effects?
    Hypotension, Cough, Angioedema, Hyperkalemia, Hyper-reninemia, Teratogenicity
  5. Angiotensin Receptor blockers are all antagonists of what AT receptor?
    AT1
  6. Which Angiotensin receptor blocker is a competitive antagonist?
    Losartan
  7. Which Angiotensin receptor blockers are non-competitive antagonist?
    Valsartan, olmesartan, candesartan, irbesartan, eprosartan, telimisartan
  8. How can you differentiate an Angiotensin Receptor blocker by name?
    ending –sartan
  9. What is the MOA for an ARBs?
    Blocks AT1 receptors, blocks angtiotensin from increasing BP and stimulating cell proliferation
  10. What effect do ARBs have on Cell growth and tissue remodeling?
    Inhibit
  11. Do ARBs have high bradykinin effects?
    No, low
  12. What are the “bradykinin effects” caused by some antihypertensives?
    Cough and angioedema
  13. What other group of drugs has the same indications as ARBs?
    ACE inhibitors
  14. What are the clinical indications for ARBs?
    Hypertension, HF, Post MI, nephropathy prevention
  15. ARBs have adverse effects similar to what other group of antihypertensives?
    ACE inhibitors
  16. What are the adverse effects of ARBs?
    Hypotension, Hyperkalemia, Hyper-reninemia and Teratogenicity
  17. What Antihypertensives should not be used in pregnant women?
    ARBs, ACE inhibitors, Aliskiren
  18. What is the relative cost of ARBs?
    Higher cost than some other Antihypertensives, fewer generics
  19. What drug inhibits Renin, and so the rate limiting step of AT II production?
    Aliskiren
  20. How often is Aliskiren administered?
    Once daily
  21. Is Aliskiren usually used as a monotherapy?
    No, usually used with other antihypertensives
  22. What is the indication for Aliskiren?
    Hypertension
  23. What are the adverse effects of Aliskiren?
    Hyperkalemia, Hypotension, Diarrhea, HA
  24. In what group of patients is Aliskiren contraindicated in?
    Pregnant, DM (cautioned), renal impaired, those on ACEIs or ARBs
  25. (True/False) Diarrhea and HA are major issues with Aliskiren use.
    False, minor issues
  26. How can you tell *some* CCBs from the name?
    ending –dipine
  27. What CCBs only block L type Calcium channels in the vascular smooth muscle?
    Amlodipine, felodipine, isradipine, nifedipine and dihydropyridines
  28. What CCBs Block L type Calcium channels in the vascular smooth muscle AND the Heart?
    Diltiazam and Verapamil
  29. When used as a monotherapy for Hypertension, rank the CCBs in terms of efficacy.
    All about the same
  30. Which CCBs are most commonly used in the treatment of hypertension?
    Dihyropyridines
  31. Are CCBs effective in African Americans?
    Yes
  32. Are CCBs effective in the elderly?
    Yes
  33. What is the relative cost of CCBs?
    Low cost, generics available
  34. Are CCBs used as an initial monotherapy?
    Yes
  35. What are the adverse effects of Verapamil and Diltiazen specifically?
    Cardiac depression, bradycardia and AV nodal block
  36. What are the adverse effects shared by all CCBs?
    Flushing, HA, dizziness, Hypotension, peripheral edema, constipation
  37. Short acting Dihydropyridine CCBs share what adverse effect?
    Increase risk of adverse cardiac events SHOULD BE AVOIDED
  38. What general type of drug is Hydralazine?
    Direct vasodilator
  39. Hydralazine relaxes arteries or veins to a greater extent?
    Arteries

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