microbio notes 1 Nov. 26 part 2 (adaptive immunity T cells B cells lymphatic system macrophages

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microbio notes 1 Nov. 26 part 2 (adaptive immunity T cells B cells lymphatic system macrophages
2013-11-26 13:20:15
microbio notes Nov 26 part adaptive immunity cells lymphatic system macrophages cytokine epitope multivalent antibody variable region antigen presentation MHC

microbio notes 1 Nov. 26 part 2 (adaptive immunity, T cells, B cells, lymphatic system, macrophages, cytokine, epitope, multivalent antibody, variable region, antigen presentation, MHC)
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  1. Can multiple B cell clones recognize a single antigen?
    yes, if the antigen contains many epitopes
  2. an immunoglobin molecule contains _ polypeptide chains
  3. an immunoglobin molecule contains 2 __ ____ and 2 ___ _____
    2 light chains and two heavy chains
  4. Each polypeptide chain of the immunoglobin molecule contains a ____ region and a _____ region
    variable and constant
  5. "__ ___" part of the antibody is susceptible to protease activity
    the hinge
  6. When "the hinge" is broken by a protease, the antibody is broken in to ___ and __ regions
    Fab and Fc regions
  7. the variable region of a polypeptide component of an antibody is coded by what genes?
    it is coded by a combination between a variable exon and a J exon
  8. what do rag proteins do?
    they conduct the random splicing of V and J genes
  9. does alternative RNA splicing also take place during the synthesis of the polypeptides necesssary for antibodies?
    yes and this adds to the variation
  10. Which provides more variety, light chains or heavy chains?
    heavy chains
  11. what is the mechanism by which antibody structure is varied on the DNA level called?
    combinatorial joining
  12. what is the protein complex that antigen presentation depends on?
  13. MHC I is located on which cells?
    all cells except for RBC
  14. MHC II is located on which cells?
    macrophages, dendrtic cells, and clonally selected cells
  15. do MHC I and II differ in function?
    no, but they have different structures
  16. MCH II is derived from what?
    the phagosome