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What are the 6 etiological agents for STDs?
Neisseria gonorrhoeae, Chlamydiadiacaea, Treponema pallidium, Haemophilus durcreyi, Garnerella vaginalis, Calymmatobacterium granulomatis
Why can't Treponema pallidium be cultured?
it has spitocytes
Haemophilus durcreyi can cause what?
What is bacterial cystitis?
- inflammation of the bladder
- most common type
Pyelonephritis (kidney infection) is a sequelae w/ what Sx's?
abupt onset, burning pain, cloudy urine due to WBC, temp, chils, vomitting, pain
What are the 6 etiological agents of cystitis?
E. coli (70%), Klebsiella, Proteus, Staph saprophyticus, Serratia, Pseudo aeuruginosa
Which ones are enterobactercocci?
E. coli, Klebsiella, Proteus, Serratia
What does Serratia produce?
a rink pigment known as prodigiosin
What is the pathogenesis of cystitis?
ascended from the urethra
Epidemiology of cystitis? occurs in who?
- both sexes
In women what is it caused by?
short urethra, sexual intercourse, use of diaphragm, wiping back to front
In men what is it caused by?
- benign prostatic hypertrophy
Gonorrhea is what kind of bacteria? what host?
- gm (-) diplococcus
- humans ONLY natural reservoir
What STD is the the 2nd most common?
How many proteins are there in gonocovvus virulence factors?
- Por protein (pI)
- Opa protein (pII)
- Rmp protein (pIII)
What does the Opa protein do?
mediates epithelium cell attachment
What does the Rmp protein do?
- Reduces modifiable
- protects Por and LOS from attaching by antibodies
What are the complications that occur with Gonorrhea?
- Fitz-Hugh-Curtis syndrome
- Disseminated infection to skin and joints
What Tx for Gonorrhea?
Pen G IM, Deoxycycline, Cirpro, and Cefriazone
What etiological agent causes chancroid?
Chancroid causes what? Seen where?
- large ulcerative lesions--> can move to lymph nodes
What does treponema pallidum cause?
Treponema pallidum has what that is motile
- motile spirochete
- cant grow in vitro
Pathogenesis of Treponema?
- Entry: mucous memb, abraided skin, sex
- Evasion: UNKNOWN
- Invasion: 1o, 2o, 3o,
- due to inflam response
- @ infection site
- incubate 2-3 weeks
- disseminated rash
- lesions in mucous membranes
- due to immune complexes binding treponemes
How else can 2nd syphilis be transmitted?
- through kissing
- 50% resolves or goes to 3o