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What are the 6 etiological agents for STDs?
Neisseria gonorrhoeae, Chlamydiadiacaea, Treponema pallidium, Haemophilus durcreyi, Garnerella vaginalis, Calymmatobacterium granulomatis
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Why can't Treponema pallidium be cultured?
it has spitocytes
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Haemophilus durcreyi can cause what?
lesions
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What is bacterial cystitis?
- inflammation of the bladder
- most common type
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Pyelonephritis (kidney infection) is a sequelae w/ what Sx's?
abupt onset, burning pain, cloudy urine due to WBC, temp, chils, vomitting, pain
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What are the 6 etiological agents of cystitis?
E. coli (70%), Klebsiella, Proteus, Staph saprophyticus, Serratia, Pseudo aeuruginosa
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Which ones are enterobactercocci?
E. coli, Klebsiella, Proteus, Serratia
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What does Serratia produce?
a rink pigment known as prodigiosin
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What is the pathogenesis of cystitis?
ascended from the urethra
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Epidemiology of cystitis? occurs in who?
- both sexes
- paraplegia/catheterization
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In women what is it caused by?
short urethra, sexual intercourse, use of diaphragm, wiping back to front
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In men what is it caused by?
- age
- benign prostatic hypertrophy
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Gonorrhea is what kind of bacteria? what host?
- gm (-) diplococcus
- humans ONLY natural reservoir
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What STD is the the 2nd most common?
Gonorrhea
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How many proteins are there in gonocovvus virulence factors?
- Por protein (pI)
- Opa protein (pII)
- Rmp protein (pIII)
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What does the Opa protein do?
mediates epithelium cell attachment
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What does the Rmp protein do?
- Reduces modifiable
- protects Por and LOS from attaching by antibodies
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What are the complications that occur with Gonorrhea?
- Fitz-Hugh-Curtis syndrome
- Disseminated infection to skin and joints
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What Tx for Gonorrhea?
Pen G IM, Deoxycycline, Cirpro, and Cefriazone
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What etiological agent causes chancroid?
Haemphilus ducreyi
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Chancroid causes what? Seen where?
- large ulcerative lesions--> can move to lymph nodes
- tropics
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What does treponema pallidum cause?
Syphilis
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Treponema pallidum has what that is motile
- motile spirochete
- cant grow in vitro
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Pathogenesis of Treponema?
- Entry: mucous memb, abraided skin, sex
- Evasion: UNKNOWN
- Invasion: 1o, 2o, 3o,
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Primary syphilis
- Chancre
- due to inflam response
- @ infection site
- incubate 2-3 weeks
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Secondary syphilis
- disseminated rash
- lesions in mucous membranes
- due to immune complexes binding treponemes
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How else can 2nd syphilis be transmitted?
- through kissing
- 50% resolves or goes to 3o
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