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Nursing interventions for antibiotic therapy
- Look for S/Sx of infection
- Check for peak and trough
Drugs that weaken (G+) cell walls
Narrow spectrum penicillins
Pen G & V
Broad spectrum penicillins
Ampicillin and Amoxicillin
A person with a mild penicillin allergy can still be given
What is the action of Cephalosporins?
- Break down cell wall (G+)
- Beta-lactamase resistant
Eliminated by kidneys
What are the adverse effects of Cepalosporins?
- Allergic reactions
- Bleeding - vitamin K interference
Other drugs that weaken the cell wall
- Carbapenems - beta lactamase resistant
What antibiotic class can be used to treat G- cells?
What is the action of Vancomycin?
Inhibits cell wall synthesis
When is Vancomycin used?
- Severe infections such as
- MRSA or C. Diff
What are the adverse effects of Vancomycin?
- Allergy (Red man syndrome)
How can you avoid thrombophlebitis?
Dilute the antibiotic
What are the four classes of bacteriostatic inhibitors of protein synthesis?
How do Tetracyclines work?
- They inhibit protein synthesis
When are Tetracyclines used?
What is chelation?
An adverse effect of Tetracyclines
- The drug is inert when taken with
- Calcium (dairy)
- Iron supplements or Magnesium containing laxatives
- Most antacids
What is the main drug under the category Macrolides?
What is the action of Erythromycin?
Inhibits protein synthesis
What can you use if the patient is allergic to penicillin?
What are the adverse effects of Macrolides?
- Prolonged QT - sudden cardiac death
What should you watch for when giving Clindamycin?
superinfection of the bowel with c diff
Is Clindomycin used for aerobic or anaerobic infections?
When is Chloromycetin used?
Only for life-threatening infections for which safer drugs are either ineffective or contraindicated
What are the adverse effects of Chloromycetin?
- Bone marrow depression
- Aplastic anemia
- GI effects
- Peripheral neuropathy
- Gray baby syndrome - form of anemia that gives skin a gray color
Drug of choice for MRSA and VRE
Acts against a broad spectrum of resistant microbes
Always check blood levels for aminoglycosides
Adverse effects of amnioglycosides
- Drug interactions with PCN
Gentamycin (amniogycoside) is used to treat what type of bacteria?
aerobic G- bacilli
Adverse effects of Gentamycin
Broad spectrum antibiotic for UTIs
- First drug for UTIs
Sulfonamide adverse effects
- Hematological effects
- Do not give to children or pregnant women
- Causes crystaluria
- Specific for UTIs
- Similar to sulfonamide
Bactrim is what 2 drugs?
Sulfonamide and Proloprim
2 phases of treatment for TB
- Induction - kills active bacteria
- Continuation - eliminates intracellular persisters
- For induction use with another agent to breakdown cell walls
- In non-resistant cases, can be used alone for continuation phase of treatment
2nd line drug for treatment of TB
Pyrazidamine adverse effects
Bacteriostatic antibiotic used as part of a multidrug regimen to treat TB
Active against all strains of TB
DOC for Hansen's disease (leprosy)
What might somebody who works around birds take prophalactically to fight Myobacterium Avium?
Cipro is the DOC for what?
DOC for protozoal infections
Metro is the DOC for what?
What would you like to do?
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