172 Topics is Pharm Sci
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What does "Immunis" mean?
means exempt referring to protection against foreign agents
The integrated body system of organs, tissues, cells and cell products that differentiates self from non-self and neutralizes potentially pathogenic organisms
The immune system
Secondary immune response:
acquired immunity response
Primary immune response:
3 ways to treat disease
inducing, enhancing or suppressing the immune system
it stimulates the body's own immune system to fight the disease
It does not rely on the body to attack the disease, instead they use the immune system components (such as antibodies) created outside the body
What did Von Behrin and Kitasato discover in 1890
the serum of vaccinated persons contained certain substances. termed antibodies
What theory did Ehrlich propose in 1900
the side chain theory
What theory did Frank Macfarlane Burnet and Jerne postulate in 1995?
natural selection theory
What did Porter isolate in 1955?
a fragment of antigen binding (FAB) and fragment crystalline (Fc) from rabbit y-globulin
What did littlefield develop in 1964?
a way to isolate hybrid cells from 2 parent cell lines using hypoxanthine - aminopterin - thymidine (HAT) selection media
What did Kohler and Milstein do in 1975?
provided the most outstanding proof of the clonal selection theory by fusion of normal and malignant cells
What are the 2 types of antibodies?
polyclonal and monoclonal
- derived from different B lymphocyte cell lines
- batch to batch variation affectding Ab reactivity and titre
- NOT powerful tools for clinical diagnostic tests
- Derived from a single B cell clone
- mAb offer reproducible, predictable and potentially inexhaustible supply f Ab with exquisite specificity
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