Chem Basis Diuretics Structures 1

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  1. Image Upload
    What is this structure?
    Loop Diuretic Pharmacophores
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    What is this structure?
    Pyridylsulfonylurea, One of the Loop diuretic pharamcophores
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    What is this structure?
    Sulfamylbenzoic acid, One of the Loop diuretic pharamcophores
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    Is this structure essential?
    Yes
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    What is this structure?
    Sulfamylbenzothiadiazine 1,1 dioxide, Thiazide Diuretic Pharmacophore
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    What is this structure?
    Pteridine Analog pharmacophore
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    What is this structure called?
    • Sulfonamide
    • (Sulfamylbenzothiadiazine 1,1 dioxide)
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    Is this structure essential for activity?
    • Yes
    • (Sulfamylbenzoic acid)
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    What type of substituent should be at this location?
    • Lipophilic
    • (Sulfamylbenzoic acid)
  10. At these two positions, what type of substitution pattern would abolish activity?Image Upload
    • Both positions carrying substituents. Only one can be substituted.
    • (Sulfamylbenzoic acid)
  11. Is this structure essential to the pharamcophore?

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    • Yes
    • (Sulfamylbenzoic acid)
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    Is this highly ionized at physiological pH?
    • Yes
    • (Sulfamylbenzoic acid)
  13. What effect does this structure have on the pharmacodynamics of this pharamcophore?Image Upload
    • Helps keep the compound localized at site of action in the kidney
    • (Sulfamylbenzoic acid)
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    What is this drug?
    Torsemide
  15. What position should this substituent be in?Image Upload
    • Ortho to the sulfamyl group
    • (Sulfamylbenzoic acid)
  16. What is the pharmacophore and what type of diuretic is this drug?Image Upload
    • Pyridylsulfonyl urea, Loop Diuretic
    • (Torsemide)
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    What is this substituent called?
    • Amino toluene
    • (Torsemide)
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    Is this substituent lipophilic or hydrophilic?
    • Lipophilic
    • (Torsemide)
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    What position should this substituent be in?
    • Ortho to the sulfonylurea
    • (Torsemide)
  20. Reducing this double bond has what effect on the molecule?Image Upload
    • Diminished activity
    • (Ethacrynic acid)
  21. What is this molecule?Image Upload
    Ethacrynic acid
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    What effect do these Hydrogens have on this structure?
    • Provides maximum reactivity
    • (Ethacrynic acid)
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    What pharmacophore does this drug have and what type of diuretic is it?
    • Phenoxyacetic acid, Loop diuretic
    • (Ethacrynic acid)
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    What is this group called and what position should it be in for optimal activity?
    • Oxyacetic acid, para to the a,b-unsaturated carbonyl
    • (Ethacrynic acid)
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    How many sulfonamides are present in this molecule?
    • 2
    • (Sulfamylbenzothiadiazine 1,1 dioxide)
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    What is this sulfonamide structure called?
    Endocyclic

    (Sulfamylbenzothiadiazine 1,1 dioxide)
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    What is this sulfonamide structure called?
    • Exocyclic
    • (Sulfamylbenzothiadiazine 1,1 dioxide)
  28. Image UploadThis sulfonamide can be Primary, Secondary or Tertiary?
    • Secondary or Tertiary
    • (Sulfamylbenzothiadiazine 1,1 dioxide)
  29. Image UploadThis sulfonamide can be Primary, Secondary or Tertiary?
    • Must be Primary
    • (Sulfamylbenzothiadiazine 1,1 dioxide)
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    If this sulfonamide were Secondary, what would R3 be?
    • H
    • (Sulfamylbenzothiadiazine 1,1 dioxide)
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    If this sulfonamide were Tertiary, what would R3 be?
    • alkyl group
    • (Sulfamylbenzothiadiazine 1,1 dioxide)

Card Set Information

Author:
kyleannkelsey
ID:
249856
Filename:
Chem Basis Diuretics Structures 1
Updated:
2013-12-01 03:10:07
Tags:
Chem Basis Diuretics Structures
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Description:
Chem Basis Diuretics Structures 1
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