Endocrine

Card Set Information

Author:
GordyG
ID:
249889
Filename:
Endocrine
Updated:
2013-11-30 23:16:36
Tags:
Pharmacology
Folders:
Pharmacology
Description:
Drugs
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  1. S/Sx of hypothyroidism
    • Dec metabolic rate
    • Bobby Hill
    • Can be due to low iodine in diet
    • Or can be idiopathic
  2. Autoimmune Hypothyroidism
    Hashimoto
  3. Treatment for hypothyroidism
    T4 - Levothyroxine
  4. T4 converts to
    T3
  5. Considerations when giving Levothyroxine
    • Accelerates degredation of Vitamin K
    • So you may need to lower warfarin doses
  6. T3
    Liothyronine
  7. Consideration for Liothyronine
    Short half life
  8. Graves/Plummers Disease
    Hyperthyroidism
  9. S/Sx of hyperthyroidism
    • increased metabolic rate
    • exopthalamus (Graves only)
  10. Treatment for hyperthyroidism
    Oral glucocorticoids
  11. Treatment for hyperthyroidism
    • Propylthiouracil
    • Methimazole
  12. Propylthiouracil and Methimazole action
    Blocks T3/T4 production
  13. Treatment plan for Propylthiouracil and Methimazole
    Give for 6 months to 2 years, then check T3/T4 levels
  14. Propylthiouracil and Methimazole are used in conjunction with what to treat symptoms of hyperthyroidism
    Beta blockers
  15. Take a CBC for patients taking Propylthiouracil or Methimazole to check for
    agranulocytosis, check for WBC count being too low
  16. Lack of Iodine leads to
    • Increased TRH and TSH release
    • Thyroid will increase in size (goiter)
  17. High levels of Iodine
    • Decrease in iodine uptake
    • Synthesis and release of T3/T4 is suppressed
  18. Treatment for Thyroid Storm
    Potassium Iodine or Iodine Salts
  19. Hyperthyroid treatment for a MALIGNANT tumor
    Iodine 131 - a radioactive iodine taken up by the thyroid
  20. GH is stimulated by
    Hypoglycemia
  21. GH is inhibited by
    • Hyperglycemia
    • Cortisol
  22. somatoSTATIN is the hormone that inhibits GH release from the AP
    somatoTROPIN is the drug that is given to somebody with a GH deficiency (dwarfism)
  23. GH causes hyperglycemia
    So GH supplement (somatoTROPIN) will be diabetagenic (causes hyperglycemia)
  24. Acromegally Tx (drugs)
    • Sandostatin - analogue of  somatoSTATIN
    • Alternative is Somavert
  25. Drug Tx for diabetes Insipidus
    DDAVP (Demopressin)
  26. Arganine Vasopressin
    Synthetic ADH
  27. Arganine Vasopressin will have what effect on B/P
    Increase, it is a vasoconstrictor
  28. Other uses for Arganine Vasopressin
    • GI bleeds (contracts smooth muscle)
    • Systemic shock or cardiac arrest (causes vasoconstriction)
  29. Role of PTH
    • Activates vitamin D
    • Promotes reabsorption of Ca+ from the bone
  30. Vitamin D effect on Ca+
    Promotes Ca+ reabsorption from the bones
  31. What two organs must be active for Vitamin D to be activated?
    • Liver
    • Kidneys
    • Sunlight must convert Vitamin D
  32. Calcitonin - opposite of Vitamin D
    • Secreted by the Thyroid
    • Inhibits reabsorption of Ca+ from the bones
  33. Tx for hypercalcemia
    • Use normal saline to increase urinary excretion
    • Can also use a loop diuretic
  34. Hypocalcemia Tx
    Ca+ supplementation and Vitamin D
  35. Osteoporosis Tx
    Fosamax
  36. Major adverse effect from Fosamax use
    Esophagitis
  37. SERMs
    Select Estrogen Receptor Modulators
  38. SERMs action
    Acts as Estrogen, preserves bone density
  39. Side effect of SERMs
    Pro-coagulant - look for DVT

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