Easy Points: Surgery - Wound Healing

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Author:
orcl777
ID:
249966
Filename:
Easy Points: Surgery - Wound Healing
Updated:
2013-12-01 10:28:37
Tags:
Wound healing olfu2016 surgery
Folders:
Surgery
Description:
Surgery: Wound Healing
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  1. Precedes and initiates inflammation with the ensuing release of chemotactic factors from the wound site
    Hemostasis
  2. Disruption of tissue integrity, leading to a division of blood vessels and direct exposure of extracellular matrix to platelets
    Wounding
  3. First infiltrating cells to enter wound site, peaking at 24 to 48 hours
    PMN
  4. Major source of cytokines, especially TNF
    PMN
  5. Release proteases such as collagenases, which participate in matrix and ground substance degradatation
    PMN
  6. Second population of inflammatory cells that invades the wound
    macrophage
  7. Achieve significant numbers in the wound by 48 to 96 hours post-injury and remain present until wound healing is complete
    Macrophage
  8. Like neutrophils, these cells participate in wound debridement via phagocytosis, and contribute to microbial stasis via oxygen radical and nitric oxide synthesis
    Macrophages
  9. Most pivotal function is activation and recruitment of other cells via mediators such as cytokines and growth factors
    Macrophage
  10. Second phase of wound healing, spans days 4-12
    proliferation
  11. Last cell populations to infiltrate the healing wound
    fibroblasts and endothelial cells
  12. The strongest chemotactic factor for fibroblasts
    PDGF
  13. Potent regulator of collagen synthesis through a mechanism involving ADP-ribosylation
    Lactate
  14. These cells proliferate extensively during this phase of healing that participate in angiogenesis
    endothelial cells
  15. VEGF receptors are located specifically on which cells?
    Endothelial cells
  16. The most abundant protein in the body
    Collagen
  17. Type of collagen that is the major component of EC matrix in the skin
    Type I
  18. Type of collagen that becomes more prominent and important during the repair process
    Type III
  19. Polypeptide chain that is translated form mRNA contains approximately 1000 amino acid residues
    Protocollagen
  20. Three helical chains entwine to form a right-handed superhelical structure
    Procollagen
  21. Structure that contains nonhelical peptide domains
    registration peptides
  22. Comprise a large portion of the "ground substance" that makes up granulation tissue
    glycosaminoglycans
  23. Major glycosaminoglycans present in the wounds
    Dermatan and chrondoitin sulfate
  24. Phase of maturation and remodeling of the scar, characterized by reorganization of previously synthesized collagen
    Fibroplastic phase
  25. Constitutes the early matrix scaffolding
    Fibronectin and collagen type III
  26. Substance that creates the final matrix
    Collagen type I
  27. The result of collagenase activity, a class of MMPs that require activation
    collagenolysis
  28. **Epithelization

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