Therapeutics Female 4

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Author:
kyleannkelsey
ID:
250052
Filename:
Therapeutics Female 4
Updated:
2013-12-01 18:56:42
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Therapeutics Female
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Therapeutics,Female,4
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Therapeutics Female 4
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  1. What is the cuase of menopause?
    Depletion of oocytes, less ovarian production of estradiol, progesterone and testosterone
  2. What vaginal changes occur with menopause?
    Reduced secretions, thinned lining and increased pH of >6
  3. What uterine changes happen at menopause?
    Decreased uterine size
  4. What group may go through menopause 2 years earlier and suffer from more hot flashes?
    Smokers
  5. What groups may be artificially stimulated to undergo menopause?
    Chemotherapy/Radiation patients
  6. When is a normal time range to undergo menopause?
    40-60 years
  7. What are non-pharmacological treatments for menopause?
    Healthy eating, regular exercise, no smoking, relaxation, cold showers, adequate sleep, yoga and acupuncture
  8. What is the MOA of progesterone in the treatment of Menopause side effects?
    Replaces reduced endogenous progesterone
  9. What is the NMCD effectiveness and safety rating for Progesterone replacement in the treatment of menopause symptoms?
    Possibly effective, insufficient evidence for safety of OTC topicals
  10. What are the consequences of use for Progesterone replacement in the treatment of menopause symptoms?
    Vaginal spotting
  11. What patients are at risk when using Progesterone replacement in the treatment of menopause symptoms?
    Disease made worse by fluid retention, Depression and Cardiovascular disease
  12. What is the NMCD effectiveness and safety rating for Black Cohosh in the treatment of menopause symptoms?
    Possibly safe (short-term) and possibly effective
  13. What is the MOA of Black Cohosh in the treatment of menopause symptoms?
    Estrogen like, but overall unknown
  14. What are the consequences of use for Black Cohosh in the treatment of menopause symptoms?
    GI upset, rash, HA, weight gain, cramping, breast tenderness, vaginal spotting, HEPATOTOXICITY
  15. What populations are at risk when using Black Cohosh in the treatment of menopause symptoms?
    Kidney transplant, liver disease, hormone sensitive cancers/breast cancer, Protein S deficient
  16. What are the safety and effectiveness rating of Soy in the treatment of menopause symptoms?
    Likely/possibly safe and possibly effective
  17. What is the MOA for Soy in the treatment of menopause symptoms?
    Estrogenic effects, similar structure to estradiol and selective estrogen receptor modulator
  18. What are the consequences of use for Soy in the treatment of menopause symptoms?
    GI upset, insomnia
  19. Is Soy in the treatment of menopause symptoms usually well tolerated?
    Yes
  20. What populations are at risk for Soy in the treatment of menopause symptoms?
    Allergic rhinitis or asthma, breast cancer, endometrial cancer and kidney stones
  21. Why are kidney stones contraindicated with Soy in the treatment of menopause symptoms?
    Soy has a high oxalate content that can contribute to kidney stones
  22. What are the safety and efficacy ratings for Eicosapentaenoic Acid in the treatment of menopause symptoms?
    Likely safe, and possibly effective
  23. What is the MOA of Eicosapentaenoic Acid in the treatment of menopause symptoms?
    Antidepressant effect, largely unknown
  24. What are the consequences of use with Eicosapentaenoic Acid in the treatment of menopause symptoms?
    GI discomfort, increase bleeding, decreased NK cell activity, fish burps
  25. What populations are at risk when using Eicosapentaenoic Acid in the treatment of menopause symptoms?
    Hypertensive, patients with bleeding disorders
  26. What are the safety and effectiveness ratings for St. John’s Wart in the treatment of menopause symptoms?
    Likley safe and possibly effective
  27. What is the MOA of St. John’s Wart in the treatment of menopause symptoms?
    Serotonergic effects (antidepressant)
  28. What are the consequences of use for St. John’s Wart in the treatment of menopause symptoms?
    Stimulatory effects, diarrhea, dry mouth, dizziness, HA
  29. (True/False) St. John’s Wart is a potent inducer of CYP450.
    True
  30. What populations are at risk when using St. John’s Wart in the treatment of menopause symptoms?
    Psychiatric conditions, surgery/anesthesia, those taking drugs metabolized by CYP enzymes
  31. What herbal remedies for Menopause are possible INeffective?
    Dong quai, Ginseng, Evening primrose, wild yam
  32. What is Vaginits?
    Inflammation of the vagina
  33. What are the signs and symptoms of Vaginitis?
    Discharge, pain, itching and sometimes infection
  34. What is the relationship or difference between Vaginitis and Vaginosis?
    Vaginitis is inflammation of the vagina, while Vaginosis is a bacterial infection of the vagina
  35. Define Atrophic vaginitis:
    thinning drying and inflammation of the vaginal walls
  36. What proportion of post-menopausal women have atrophic vaginitis?
    40%
  37. What is the pathophysiology of Atrophic vaginitis?
    Caused by declining estrogen levels
  38. What are the signs and symptoms of atrophic vaginitis?
    Discharge, Dryness, Itching, Lubrication, painful intercourse, mild bleeding after intercourse, urinary issues
  39. What groups are at risk for atrophic vaginitis?
    Postmenopausal women, smokers, un-sexually active, no vaginal births
  40. What are the treatments for atrophic vaginitis?
    Vaginal Lubricants
  41. What are useful vaginal lubricants for Atrophic Vaginitis?
    Glycerin, Hydroxymethylcellulose, Mineral oil, Chlorhexadine, Gluconate, propylene glycol, Vitamin E and Aloe vera
  42. Is Vaseline a good treatment for Atrophic Vaginits?
    No, gloopy, hard to remove and can break down latex
  43. What are common ingredients for douching?
    Water/vinegar, betadine and acetic acid

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