Pregnancy

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Author:
Anonymous
ID:
250773
Filename:
Pregnancy
Updated:
2013-12-04 15:46:12
Tags:
Howrie
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Description:
Howrie
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  1. Principles of teratogenicty
    • 1 teratogen --> many malformations
    • many teratogens --> 1 malformations
    • not always bad for mom
    • exposure happens in critical period
    • dose relationship assumed, not always defined
    • species and/or strain specific malformation in animal models
  2. FDA risk
    • A: studies in humans show no risk
    • B: no studies in humans, studies in animals show no risk
    • C: no studies in humans or animals
    • D: evidence of risk in fetus (benefit to mother might outweight risk)
    • X: studies in both humans and animals show fetal abnormalities (risk in mother and fetus outweighs benefit)
  3. Drug PK changes in pregnancy
    increase: blood volume, RBC, CO, HR, GFR, blood flow

    decrease: gastric emptying/transit time, BP, albumin, antithrombin III, factor S

    • A: same
    • D: inc Vd, dec Cmax
    • M/E: dec half life, inc Cl
  4. Class A examples
    thyroid supplementation
  5. class B examples
    • APAP
    • narcs
    • insulin
    • immodium
    • dramamine
    • cephs
    • PCN's
    • sulfa
    • EES
  6. class C examples
    • reglan
    • tigan
    • antihistamin
    • antihn
    • INH
    • cocaine
    • beta blocker
    • lasix
    • theophyline
  7. class d examples
    • anti-epileptics
    • warfarin
    • TCN
    • anti-cancer
    • thiazides
    • valium
    • lithium
  8. Class x examples
    • accutane
    • DES
    • OCP
    • valproate

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