Cystic Fibrosis

Card Set Information

Cystic Fibrosis
2013-12-04 17:43:00
Dr Davis
Show Answers:

  1. what are the common pathogens colonized in CF pts
    • p. aeruginosa
    • s. aureus
    • h. flu
  2. what are the non common pathogens seen in CF pts
    • b. cepacia
    • aspergillus
  3. drug used for for CFTR modulation
    ivacaftor (Kalydeco)
  4. what is the MOA of ivacaftor
    increases Cl- ion transport via G551D-CFTR protein channel opening
  5. who is kalydeco approved for
    pts 6+ with the G551D mutation
  6. what should ivacaftor not be administered with
    strong CYP3A4 inducers
  7. what drugs are used for Pulmonary therapy
    • bronchodilators
    • dornase alfa
    • hypertonic saline
    • corticosteroids
    • high dose ibuprofen
    • azithromycin
  8. which drug is recommended for pts with persistent P. aeruginosa cultures
  9. what is the MOA of pulmozyme
    dornase alfa is a recombinant DNA enzyme that  cleaves extracellular DNA from neutrophils in secretions that block airways
  10. what is the MOA of hypertonic Saline (IHS)
    increases hydration of airway surface liquid via osmotic flow

    helps improve mucus clearance
  11. MOA of azithromycin in pulmonary drug therapy
    • suppresses inflm
    • alters biofilm formation
  12. duration of therapy for antimacriobial tx for CF pts
    14 - 21 days
  13. oral agents used to tx MSSA
    • augmentin
    • keflex
  14. oral therapy used to treat MRSA
    • clindamycin
    • bactrim
    • linezolid
  15. oral abx used to tx p. aeruginosa
  16. oral abx used to tx h. flu
    • augmentin
    • cefuroxime
  17. inhaled abx used to tx p. aeruginosa
    • tobramycin (TOBI)
    • aztreonam (Cayston)
    • colistimethate (colistin)
  18. IV agents used to tx s. aureus for CF pts
    • nafcillin (MSSA)
    • vancomycin
    • linezolid
    • clindamycin
  19. IV agents used to tx p. aeruginosa in CF pts
    • zosyn
    • cefepime
    • cipro
    • meropenem
    • tobramycin or amikacin
  20. IV agents used to tx s. maltophilla in CF pts
    • bactrim
    • zosyn
    • levo or moxi
    • ticarcillin/ clavulanate + aztreonam
  21. IV agents used to treat b. cepacia in CF pts
    • bactrim
    • meropenem
    • ciprofloxacin
  22. antifungal agents used to tx aspergillus in CF pts
    • itraconazole
    • voriconazole
  23. antifungal agent used to tx scedosporium apiospermum in CF pts
  24. FDA approved products used for pancreatic enzyme replacement
    • creon
    • zenpep
    • pancreaze
    • pertzye
    • ultrease
    • viokace