Cystic Fibrosis

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Author:
alvo2234
ID:
250878
Filename:
Cystic Fibrosis
Updated:
2013-12-04 23:54:22
Tags:
Dr Davis
Folders:
PT,IV,final,exam
Description:
final
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  1. common pathogens colonized in CF pts
    • pseudomonas
    • s. aureus
    • h. flu
  2. uncommon pathogens seen in CF exacerbations
    • b. cepecia
    • aspergillus
  3. MOA of ivacaftor
    kalydeco increases Cl- ion transport via G551D-CFTR
  4. who is kaldeco indicated for
    pt 6+ with the G551D mutation
  5. what do you NOT co-administer with kalydeco
    strong CYP3A4 inducers
  6. MOA of Dornase alfa
    pulmozyme is a recombinant DNA enzyme which selectively cleaves extracellular DNA from neutrophils  in secretions that block airways
  7. what is the MOA of hypertonic saline
    IHS increases hydration of airway surface liquid via osmotic flow
  8. what agents are used in pulmonary drug therapy
    • bronchodilators
    • dornase alfa
    • hypertonic saline
    • corticosteroids
    • high dose ibuprofen
    • azithromycin
  9. which agent is used in pts with persistent pseudomonas cultures
    azithromycin
  10. oral agents used for MSSA
    • augmentin
    • keflex
  11. oral agents used for MRSA
    • bactrim
    • clindamycin
    • linezolid
  12. oral agents used for pseudomonas
    cipro
  13. oral agents used to h. flu
    • augmentin
    • cefuroxime
  14. IV agents used for MSSA
    nafcillin
  15. IV agents used for MRSA
    • vanco
    • linezolid 
    • clindamycin
  16. IV agents used to treat pseudomonas
    • cipro
    • zosyn
    • cefepime
    • meropenem
    • tobramycin or amikacin
  17. IV agents used for s. maltophilla
    • bactrim
    • zosyn
    • levo or moxi
    • timentin + aztreonam
  18. IV agents used for H. flu
    • cipro
    • meropenem
    • zosyn
    • cefepime
    • tobramycin or amikacin
  19. inhaled agents used to treat pseudomonas
    • Tobramycin (TOBI)
    • aztreonam (cayton)
    • colistimethate (colistin)
  20. antifungal agents used for aspergillus
    • itraconazole
    • voriconazole
  21. antifungal agent used for scadosporium
    voriconazole
  22. IV agents used for b. capecia
    • bactrim 
    • meropenem
    • cipro
  23. FDA approved products for pancreatic insuficiency
    • creon
    • zenpep
    • pancreaze
    • pertzye
    • ultrease
    • viokace
  24. what is the ratio for supplemental pancreatic enzyme preparations
    lipase, protease, and amylase (1:3:3)
  25. nutritional supplements used for pancreatic insufficiency
    vitamins A, D, E, K and iron
  26. Tx for GERD
    • H-2 receptor antagonist
    • proton pump
  27. what are proton pumps also utilized for
    enzyme boosting
  28. tx options to stimulate poor appetite
    • megestrol 
    • cyproheptadine
    • dronabinol
    • mirtazipine
  29. tx used for N/V associated with gastroparesis
    • ondansetron
    • prochlorperazine
  30. tx used to increase motility associated with gastroperesis
    • metoclopramide
    • erythromycin
  31. which drug is used for hepatobiliary disease secondary to CF
    ursodiol (actigall)
  32. what is the standard tx for diabetes secondary to CF
    insulin
  33. what effect does actigall have on the liver enzymes
    they reduce liver enzymes

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