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Describe each enzyme w/ group and important information presented?
- Amylase: Jodi and co (linking arms group)
- specific and general acid/base
- Citrate synthase:
- general acid/base
- glutamine synthase: Unicorn group
- Glutamate is P'd, but is ultimately removed to form Glutamine
- hexosaminidase A (hex a):
- General and specific acid/base
- Urease: The Dusos (muggers)
- Metal catalyzed, and general Acid/base
What is the mechanism for the enzyme that your group presented. Give a detailed answer, including important chemical structures.
- Enzyme binds ATP and galactose
- Asp186 (-) removes proton from OH on C-1
- Newly nucleophilic O- on C-1 attacks Pi
- ADP and G-1-P released
- Asp186 releases H due to pKa
*general base mechanism
Give an example of an enzyme mechanism that has metal ion catalysis.
Give an example of an enzyme mechanism that has general acid catalysis.
5. Give an example of an enzyme mechanism that has general base catalysis.
- Citrate Synthase
- ?Glutamine synthetase
Give an example of an enzyme mechanism that has covalent catalysis
Give an example of an enzyme mechanism that has specific acid or specific base catalysis.
Which enzyme catalyzes a reaction that cleaves ATP, but phosphate is not on the final product?
Which enzyme catalyzes a condensation of a two carbon molecule and a four carbon molecule?
Which enzyme catalyzes a reaction that raises the pH for enhanced bacterial growth?
Which enzyme catalyzes a reaction removes a sugar from a ganglioside
Which enzyme cleaves an α(1-4) glycosidic linkage
Which enzyme catalyzes a reaction that cleaves ATP, and phosphate is on the final product?