When would you tend to see a high number of reticulocytes? What does this mean?
In an anemic pt.
The immature cells are coming out of the BM earlier than normal as a compensatory mechanism.
What is the most important regulator of RBC production?
Tissue oxygenation. RBC function is to carry O2 attached to Hgb.
Normal RBC value for men.
4.7 - 6.1 million cells / microliter
Avg= 5.2 million
Normal RBC value for women.
4.2 - 5.4 million cells / microliter
Avg= 4.7 million
What is MCV?
mean corpuscular volume, aka avg RBC size
What is MCH?
mean corpuscular Hgb, avg amount (mass) of Hgb in a RBC
What is MCHC?
mean corpuscular Hgb concentration
Increased MCV (often from nutritional anemias from B12 and folate deficiency)
characterized by decreased MCH
In low O2 states, ______ will stimulate the production of RBCs.
Where is erythropoietin made (2 sites)
90% in the kidney
10% in the liver
T or F, in kidney failure the liver can compensate to produce enough erythropoietin for adequate RBC production?
What substances will stimulate erythropoietin production?
NE, epi, and prostaglandins
stimulates erythropoietin production in the kidney
Decreased O2 carrying capacity from any cause
Do RBCs have a nucleus?
Avg RBC lifespan?
RBCs carry a large amount of this enzyme. It catalyzes the reaction of CO2 and water to form carbonic acid. This allows the blood to carry large amounts of CO2 in the form of bicarb ion from the tissues to the lungs. Then it gets converted back to CO2 and is exhaled.
Major buffer found in whole blood?
RBCs, Hbg is a protein, and like other proteins, is a really good buffer.
Avg H+H for a male
45 / 15
Each gram of Hgb can carry about ____ ml of O2.
An individual can carry about ___ ml of O2 per 100 ml of _____.
Glucose-6-phosphate dehydrogenase is an enzyme in the glycolytic pathway.
A deficiency in G6PD will disrupt the glycolytic pathway that's needed for RBC metabolism.
Hemolytic anemia results (G6PD is needed for the stability of the RBC, so without it, RBCs have decreased life span).
fractional volume of RBC mass
Major blood components
"Buffy coat"- WBCs and Plts- 1%
Hct= ____ x 3
stimulation to produce erythropoietin
Optimal erythropoiesis occurs when there is sufficient ____, _____, and ____.
B12, iron, and folate.
T or F, SCD is AD?
SCD involves substitution of ____ for ____ in the beta globulin subunit, making it Hgb S.