Pharmacology Final

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Author:
GordyG
ID:
251617
Filename:
Pharmacology Final
Updated:
2013-12-08 09:09:56
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Final
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Description:
Drugs
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  1. Pharmacology
    The study of drugs and their interactions with living systems
  2. Clinical Pharmacology
    The study of drugs in humans
  3. Pharmacotherapeutics
    The use of drugs to diagnose, prevent, or treat disease or prevent pregnancy
  4. Factors influencing drugs response
    • Administration
    • Pharmacokinetics
    • Pharmacodynamics
    • Individual Variations
  5. Administration of a drug
    • Route
    • Timing
    • Dosage
  6. Pharmacokinetics
    • Absorption
    • Distribution
    • Metabolism
    • Excretion
  7. how does a chemical cross the BBB
    • lipid soluable
    • or
    • direct transport mechanism
  8. Actions of the P450
    • Inactivate a drug
    • Increase the therapeutic action
    • Activate prodrugs
    • Accelerate renal excretion
    • Increase or decrease toxicity
  9. Maximal efficacy
    largest dose that a drug can elicit regardless of dose
  10. Agonist
    Antagonist
    Partial Agonist
    Agonist-molecules that activate receptors-mimic the action of endogenous molecules

    Antagonist-prevents receptor activation

    •   Competitive-binds reversibly by highest
    •   concentration

      Noncompetitive-binds irreversibly

    • Partial agonist- (partial antagonist) - achieves less than the effect of an agonist,
    • but can compete for agonist sites
  11. MEC
    minimal effective concentration, will have no effect below this
  12. Therapeutic Index
    Lethal Dose / Effective Dose
  13. Higher Therapeutic Index
    Means it is safer
  14. Pharmacodynamics
    The impact of a drug at the site of action
  15. Pharmacokinetics
    entering the system

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