Chem Basis PPIs 3

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Author:
kyleannkelsey
ID:
251688
Filename:
Chem Basis PPIs 3
Updated:
2013-12-08 15:09:11
Tags:
Chem Basis PPIs
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Chem,Basis,PPIs,3
Description:
Chem Basis PPIs 3
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  1. What effect does the ether oxygen have on this molecule?
    Donates electrons through the pi system to ↑ nucleophilic character of the pyridine N (Lansoprazole)

  2. What effect do the three fluorine atoms have on Lansoprazole?
    Exhibit electronic pull and give protection against metabolism

  3. What effect does the methyl group have on this molecule?
    Pushes electrons toward the pyridine N through the sigma bonds (Lansoprazole)

  4. How does the onset of action of Lansoprazole compare to Omeprazole and Rabeprazole?
    Slower

  5. What CYP enzymes metabolize this drug?
    2C19 and 3A4 (Lansoprazole)

  6. What changes to this molecule does CYP2C19 cause?
    Hydroxylation of the benzimidazole C5 (Lansoprazole)

  7. What clinical DDIs are associated with Lansoprazole?
    None, can competitively inhibit 2C19 and induce 1A’s, but no evidence of interactions

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