Chem Basis PPIs 4
Home > Preview
The flashcards below were created by user
on FreezingBlue Flashcards.
Why can pantoprazole form a water soluble salt?
It’s imidazole NH group is uniquely acidic enough
What functional significance does the Methoxy group at R1 have?
Donates e- to pyridine N through pi bonds
What functional significance does the Methoxy group at R2 have?
Exerts inductive penalty, pulls electrons through sigma bonds, ↓ pKa 1 and ↓ activity
What effect does the 5-difluromethoxy group have on the Benzimidazole N3?
↓ ability of N3 to become protonated
Why is the activation of this drug slow?
Due to low reactivity of the benzimidazole N3
The slow activation of pantoprazole allows for what?
The drug to reach the deeper CYS residue
Why is the duration of action longer for Pantoprazole than other PPIs?
The deeper CYS residue is bound, parietal cells are not subject to glutathione rescue
What CYP enzymes metabolize Pantoprazole?
CYP2C19 and CYP3A4
How does CYP2C19 alter this drug?
O-dealkylation of the C5 methoxy
How does CYP3A4 alter this drug?
What significant DDIs does this drug have?
What would you like to do?
Home > Flashcards > Print Preview