Chem Basis PPIs 5

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    Methoxypropoxy substituent has what effect on this molecule?
    Provides greatest amount of pi electron push of all currently marketed products = fewer unionized pyridine N, but those that are unionized are electronically super-charged, ready for the intramolecular mucleophilic attack at the benzimizdazole C2 (Rabeprazole)
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    What is the pKa1?
    4.53 (Rabeprazole)
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    What is the pKa2?
    0.62 (Rabeprazole)
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    How does this drugs onset of action compare to other currently marketed PPIs?
    Fastest onset of action of any other current PPI (Rabeprazole)
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    How is this drug metabolized?
    Nonenzymatic conversion to thioether -No CYP- (Rabeprazole)
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    Does this drug have DDIs?
    No, not metabolized by CYP which helps (Rabeprazole)

Card Set Information

Author:
kyleannkelsey
ID:
251692
Filename:
Chem Basis PPIs 5
Updated:
2013-12-08 20:13:03
Tags:
Chem Basis PPIs
Folders:
Chem,Basis,PPIs,5
Description:
Chem Basis PPIs 5
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