Chem Basis PPIs 5
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Methoxypropoxy substituent has what effect on this molecule?
Provides greatest amount of pi electron push of all currently marketed products = fewer unionized pyridine N, but those that are unionized are electronically super-charged, ready for the intramolecular mucleophilic attack at the benzimizdazole C2 (Rabeprazole)
What is the pKa1?
What is the pKa2?
How does this drugs onset of action compare to other currently marketed PPIs?
Fastest onset of action of any other current PPI (Rabeprazole)
How is this drug metabolized?
Nonenzymatic conversion to thioether -No CYP- (Rabeprazole)
Does this drug have DDIs?
No, not metabolized by CYP which helps (Rabeprazole)
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