Chem Basis PPIs 7

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Author:
kyleannkelsey
ID:
251728
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Chem Basis PPIs 7
Updated:
2013-12-08 16:45:52
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Chem Basis PPIs
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Chem Basis PPIs 7
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  1. What is the H+, K+-ATPase responsible for?
    Transferring gastric acid from canaliculus (acid holding-chamber network) to the stomach lumen
  2. H+ is transported from the cytoplasmic domain to extracytoplasmic domain bound while bound to what three residues?
    ASP824, GLU820 & GLU795
  3. ASP824, GLU820 & GLU795 are anionic or cationic?
    Anionic
  4. K+ is transported from the cytoplasm to extracytoplasm bound while bound to what residues?
    GLU820 & GLU795
  5. CYS813 or CYS822 is reached more readily by all PPIs?
    CYS813
  6. What type of PPIs are most likely to reach CYS822?
    Slower/Less reactive
  7. (True/False) GSH rescue is possible in all inactivated ATPase molecules.
    False, should say: in a given percentage, but not all
  8. (True/False) Irreversible inactivation of many proton pump proteins leads to high potency and a long DOA.
    True
  9. If the pH is less than pka of a given PPI, will the PPI be in a protonated or neutral form?
    Protonated
  10. If the pKa of a given PPI is less than pH, will the PPI be in a protonated or neutral form?
    Neutral
  11. Methyl pyridyl has a pka of 4, will it be protonated in the stomach (pH 1.5)?
    Yes, because the pH is less than the pKa
  12. Methyl pyridyl has a pka of 4, will it be protonated in the blood (pH 7.4)?
    No, because the pKa is less than the pH
  13. What is the pH of the stomach?
    1.5
  14. What is the pH of the blood?
    7.4
  15. Benzimidazole has a pka of less than 1, will it be protonated in the blood (pH 7.4)?
    Never, because the pKa is less than the pH
  16. Benzimidazole has a pka of less than 1, will it be protonated in the stomach (pH 1.5)?
    Would be transiently protonated in the stomach, but predominately not since the pKa is less than the pH
  17. Why is it important that the N3 of the Benzimidazole be protonated or not?
    N3 must be protonated for PPI action
  18. (True/False) PPIs have two basic nitrogens that have the potential to protonate at very low pH of the canaliculus (pH 1.5).
    True
  19. What is the pKa of the Pyridine N1?
    pKa1: 3.83-4.53
  20. What is the pKa of the Benzimidazole N3?
    pKa2: 0.11-0.79
  21. The pyridine nitrogen (N1) has a pKa of 3.83-4.53, will it be primarily cationic or unionized at the stomach pH of 1.5?
    Cationic, because the pH is lower than the pKa

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