Antifungal agents

Card Set Information

Author:
ucstudent01
ID:
251757
Filename:
Antifungal agents
Updated:
2013-12-08 18:08:16
Tags:
Antifungal agents
Folders:
Antifungal,agents
Description:
Antifungal agents
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user ucstudent01 on FreezingBlue Flashcards. What would you like to do?


  1. Antifungal agents - Polyenes

    Name one & Mechanism of action
    Amphotericin B

    Attach to ergosterol and form pores, then electrolytes and cytoplasm leak out.
  2. Antifungal agents - Azoles

    Name a few and Mechanism of action
    Fluconazole, Itraconazole, ketoconazole, voriconazole

    • Inhibits P450 (synthesizes ergosterol)
    • Depletion of important sterol in cell membrane
  3. Antifungal agents - Antimetabolite

    Name and mechanism of action
    Flucytosine

    • 5 flurouracil inhibits replication of RNA, so...
    • NO protein synthesis
    • No RNA
  4. Antifungal agents - Echinocandin

    Name & mechanism of action
    Caspofungin, micafungin, anidulafungin

    Caspo fungin inhibits synthesis of 1,3-β-glucan - Thus Cell wall is not formed
  5. Anti-mitotic agent

    Only one available -

    Name & mechanism of action
    Griseofulvin - layered onto skin

    Inhibits fungal cell mitosis

    *toxic to liver

What would you like to do?

Home > Flashcards > Print Preview