Chapter 16 Cell communication part 2

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iishvo
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251840
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Chapter 16 Cell communication part 2
Updated:
2013-12-08 22:01:47
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cell bio part
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cell bio notes davis
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  1. Cell responses mediated by phospholipase c activation
    • signalmolecules:
    • vasopressin
    • acetylcholine
    • and thrombin
  2. vasopressin
    a peptide hormone that targets the liver and breaks down glycogen
  3. acetylcholine
    targets pancreas to secrete amylase or targets smooth muscle for contraction
  4. thrombin
    a proteolytic enzyme targets blood platelets and causes aggregation
  5. phosphatidylinositol
    phospholipid
  6. inositol
    sugar alcohol
  7. phospholipase C activation
    cleavage of inositol triphosphate from the phospholipid which leaves glycerol with two fatty acids attached
  8. Diacylglycerol (DAG)
    glycerol with two fatty acids attached
  9. What pathway is important in memory function?
    • Calmodulin action
    • release of calcium which then binds to calmodulin induces a conformational change that enables it to bind to otherwise inactive kinases (CaM-kinases). phosphorylation of CaM-kinases sets off yet another signaling cascade.
  10. single photoreceptor rod cell contains
    multiple membrane discs of rhodopsin
  11. rhodopsin
    a protein that captures light and transmits the signal through a g-protein called transducin
  12. the alpha subunit of transducin
    closes cation channels which changes the membrane potential . very fast signal on the order of 20 msec and you get a tremendous amplification of the signal. net change in membrane potential is about 1 mV

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