Pharmacokinetics Geriatrics 1

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  1. What are elderly people?
    65 years +
  2. What is Young/Old?
  3. What is Very old?
  4. What is old?
  5. Aging happens at a fairly constant or variable rate?
  6. What are the factors of aging?
    Genetics, nutrition, disease states, injuries, stress, socioeconomics
  7. Can glucose effect aging?
  8. Can injury affect aging?
  9. What percent of Americans are 65 years or older?
    13.3% or 40 million
  10. Do most people end up in a nursing home?
    No, but very old do often end up in nursing homes
  11. What is the average lifespan?
  12. What is the fastest growing segment of our population?
    85 and older
  13. People age 100 and older is projected to be how many people in the US in 2030?
  14. What percent of people over 65 have a severe chronic conditions?
  15. What are the most common severe chronic conditions in persons over 65?
    HTN, arthritis, Heart disease, Cancer, Diabetes, Asthma, Stroke
  16. What are the top 5 causes of death for adults over 65?
    Heart disease, Cancer, CV disease, COPD and Pneumonia
  17. What are the 6-10 causes of death in over 65 years?
    Diabetes, Accidents, Septicemia, Nephritis, Alzheimer’s
  18. What percent of people who never go back to the same level of living after a hip fracture?
  19. How do the eyes change with age?
    Reduced accommodation leading to farsightedness, yellowing lens, cataracts, glaucoma and age related macular degeneration
  20. Why do older people need more light to see?
    Yellowing lens
  21. When are cataracts more likely?
    Use of prednisone or eye injury
  22. A person with blurry central vision has what disease?
    Macular degeneration
  23. What auditory changes happen in the elderly?
    Impaired sensitivity and reduced hearing at high frequencies
  24. What central NS changes occur in elderly?
    Cerebral blood flow decreases, BBB more permeable, short term memory declines (not dementia), brain atrophy
  25. Brain atrophy is elderly is usually pathologic?
    No, often normal aging process
  26. What changes in the kidney occur with age?
    Decrease in: GFR, Renal blood flow and renal mass
  27. What changes in the Cardiovascular system occur with age?
    Decreased: Myocardial sensitivity to Beta stimulation, baroreceptor activation, CO, Total PR
  28. Epinephrine works better or worse in older adults and why?
    Worse, b/c Beta stimulation is less responsive
  29. Why is Orthostatic hypotension more common in older adults?
    b/c Beta stimulation is less responsive
  30. What pulmonary changes occur in elderly adults?
    Increase chest wall rigidity and decrease in gas exchange
  31. What changes occur in body composition of elderly?
    Increased fat, decrease in TBW and lean tissue
  32. What GI changes occur in older adults?
    Decreased: saliva, esophageal motility, HCL secretion and gastric emptying rate
Card Set
Pharmacokinetics Geriatrics 1
Pharmacokinetics Geriatrics 1
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