Antibiotics

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Author:
Mundi
ID:
252057
Filename:
Antibiotics
Updated:
2013-12-18 12:34:01
Tags:
antibiotic drugs
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Description:
Pharm antibiotic drugs
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  1. Aminoglycosides
    P: Gentamycin

    MOA: protein synth interference

    Use: life threatening gram - 

    AE: CNS (aud, LOC)

    BBW: ototoxic (ear), nephrotoxic (kidneys)

    D2D: loop diuretics (Lasix)
  2. Carbapenems
    P: Ertrapenem

    MOA: cell wall destruc

    USE: gram - +; CAP; bone & joint; Imipenem-C for kids; C.diff diarrhea

    AE: H2O electrolyte imbalance

    Contra: allergy to PCN
  3. Cephalosporins
    • P: Cefaclor
    • Vancomycin

    MOA: cell wall destruc

    USE: preop prphylaxis

    AE: toxic GI, skin rash, kidneys

    D2D: no nephrotoxic drugs (Aminogly), no anticoagulants (↑ bleeding), no alcohol
  4. Fluoroquinolones
    P: Ciprofloxacin

    MOA: DNA interference

    USE: gram - ; Anthrax, typhoid fever

    BBW: Tendonitis & rupture; ↑ risk in elderly; steroids, kidney, heart, lung transplant


    D2D: no iron, no antacids
  5. PCN & PCN-resistant
    P: Amoxicin

    MOA: cell wall 

    CONTRA: hypersensitivity, anaphylaxis

    D2D: aminogly (↓ effect), cyclosporine (↑ nephrotoxicity)
  6. Sulfonamides
    • P: Contrimoxazole
    • (Steven Johnson's Syndrome)

    MOA: folic acid inhibit.

    USE: UTI & trachoma
  7. Tetracycline
    Tetracycline

    No preg, lact, children (teeth & bones)

    • Photosent
    • Rashes

    • No oral BC (less effective)
    • No antacids
    • No PCN
  8. Antimycobacterial
    • Isoniazid (peripheral neuro; preg OK)
    • Rifampin (orange color; preg OK)
    • Pyrazinamide
    • Ethambutol (Optic neuritis; preg OK)

    TB & leprosy

    CNS; optic
  9. Ketolides
    Telitheromycin

    mild-mod CAP

    BBW: D/N give to MYASTHENIA GRAVIS (resp fail)
  10. Lincosamides
    Clindamycin

    life-threatening infections
  11. Macrolides
    • Erythromycin
    • Azithromycin

    • Prophylaxis (dental or heart procedure)
    • empty stomach
  12. Lipoglycopeptides
    Televancin

    • Skin infections only
    • -AE: foamy urine

    BBW: NO PREG & LACT
  13. Fidaxomicin
    C.Diff
  14. Linezolid
    Diabetic foot ulcers

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