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Kwalke12
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What is positive for mono by Davidsohn differential
- Sheep = P
- G.Pig = P
- BE Cow = N
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What is positive for Fossman by Davidsohn differential
- Sheep = P
- G.Pig = N
- BE Cow = P
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What is positive for Serum Sickness by Davidsohn differential
- Sheep = P
- G.Pig = N
- BE Cow = N
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Does Serum sickness or Forssman Ab's react with mono ab's?
NO - They do not react with mono Ab's
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What is serum sickness?
It is a passive type III hypersensitivity reaction due to ie. vaccine (antitoxin)
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Explain the new test immunochromagraphic Assay
Detects heterophile Ab
bovine antigen RBC's bind to mono ab's. then with multiple binding sites from IgM mono Ab's, they cause a sandwhich assay
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What is TORCH
- Infant screening test:
- Toxoplasmosis
- other inf.
- rubella
- CMV
- HSV
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What lab tests are used for ident of CMV
- Viral PCR or Viral Cultures
- Tests for IgM or IgG to CMV
- >IgM = Current or re-exposure
- 4 fold rise in IgG = Current infection
- Low affinity IgG indicates acute infection
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Rubella Disease and diagnosis
Part of togaviridae family
Rash (usually young children)
- EIA: IgM or 4 fold rise in IgG
- Cutoff of 15IU/ml indicated immunity
Live Vaccine
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Rubeola (Measles)
Family/Disease/Lab Tests
Paramyxoviridae family
MMR vaccine available
Spread by aerosol
Dx: Characterisitic Rash, EIA for Ab's, PCR
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Mumps
Family/Disease/Lab test
Paramyxovirus Family
Direct contact with secretions
- Viral Cx
- RT-PCR to detect TNA in virus
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West Nile Virus
Family
Flavivirus
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Influenza
Family/ What happens during infection
Orthomyxoviridae
- During inf:
- *Hemagglutinin: Binds to surface sialic acid
- (H1,H2,&H3 subtypes)
*Neuraminidase: Cleaves sialic acid for virus exit from cell (N1 & N2 subtypes)
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Changes in Influenza are due to what?
- Antigenic Drift:
- *Mutations in the genome of the virus and other minor changes
- Antigenic Shit:
- * Reassortment in doubly infected cell in which a virion is packed with a segment of RNA from a different virus, creating a new virus.
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Lab test for Influenza
Rapid - Detects Influenza antigen
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