Herpesviradae

• Sheep    = P
• G.Pig     = P
• BE Cow  = N

• Sheep    = P
• G.Pig     = N
• BE Cow  = P

• Sheep    = P
• G.Pig     = N
• BE Cow  = N

NO - They do not react with mono Ab's

It is a passive type III hypersensitivity reaction due to ie. vaccine (antitoxin)

Detects heterophile Ab 

bovine antigen RBC's bind to mono ab's. then with multiple binding sites from IgM mono Ab's, they cause a sandwhich assay

• Infant screening test:
• Toxoplasmosis
• other inf.
• rubella
• CMV
• HSV

• Viral PCR or Viral Cultures
• Tests for IgM or IgG to CMV

• >IgM = Current or re-exposure
• 4 fold rise in IgG = Current infection
• Low affinity IgG indicates acute infection

Part of togaviridae family

Rash (usually young children)

• EIA: IgM or 4 fold rise in IgG
• Cutoff of 15IU/ml indicated immunity

Live Vaccine

Paramyxoviridae family

MMR vaccine available

Spread by aerosol

Dx: Characterisitic Rash, EIA for Ab's, PCR

Paramyxovirus Family

Direct contact with secretions

• Viral Cx
• RT-PCR to detect TNA in virus

Flavivirus

Orthomyxoviridae

• During inf:
• *Hemagglutinin: Binds to surface sialic acid
• (H1,H2,&H3 subtypes)

*Neuraminidase: Cleaves sialic acid for virus exit from cell (N1 & N2 subtypes)

• Antigenic Drift:
• *Mutations in the genome of the virus and other minor changes

• Antigenic Shit:
• * Reassortment in doubly infected cell in which a virion is packed with a segment of RNA from a different virus, creating a new virus.

Rapid - Detects Influenza antigen