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Herpesviradae
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What is positive for mono by Davidsohn differential
Sheep = P
G.Pig = P
BE Cow = N
What is positive for Fossman by Davidsohn differential
Sheep = P
G.Pig = N
BE Cow = P
What is positive for Serum Sickness by Davidsohn differential
Sheep = P
G.Pig = N
BE Cow = N
Does Serum sickness or Forssman Ab's react with mono ab's?
NO - They do not react with mono Ab's
What is serum sickness?
It is a passive type III hypersensitivity reaction due to ie. vaccine (antitoxin)
Explain the new test immunochromagraphic Assay
Detects heterophile Ab
bovine antigen RBC's bind to mono ab's. then with multiple binding sites from IgM mono Ab's, they cause a sandwhich assay
What is TORCH
Infant screening test:
Toxoplasmosis
other inf.
rubella
CMV
HSV
What lab tests are used for ident of CMV
Viral PCR or Viral Cultures
Tests for IgM or IgG to CMV
>IgM = Current or re-exposure
4 fold rise in IgG = Current infection
Low affinity IgG indicates acute infection
Rubella Disease and diagnosis
Part of togaviridae family
Rash (usually young children)
EIA
: IgM or 4 fold rise in IgG
Cutoff of 15IU/ml indicated immunity
Live Vaccine
Rubeola (Measles)
Family/Disease/Lab Tests
Paramyxoviridae family
MMR vaccine available
Spread by aerosol
Dx: Characterisitic Rash, EIA for Ab's, PCR
Mumps
Family/Disease/Lab test
Paramyxovirus Family
Direct contact with secretions
Viral Cx
RT-PCR to detect TNA in virus
West Nile Virus
Family
Flavivirus
Influenza
Family/ What happens during infection
Orthomyxoviridae
During inf:
*Hemagglutinin
: Binds to surface sialic acid
(H1,H2,&H3 subtypes)
*Neuraminidase: Cleaves sialic acid for virus exit from cell (N1 & N2 subtypes)
Changes in Influenza are due to what?
Antigenic Drift:
*Mutations in the genome of the virus and other minor changes
Antigenic Shit:
* Reassortment in doubly infected cell in which a virion is packed with a segment of RNA from a different virus, creating a new virus.
Lab test for Influenza
Rapid - Detects Influenza antigen
Author
Kwalke12
ID
252417
Card Set
Herpesviradae
Description
Herpesviradae
Updated
12/10/2013, 11:55:07 PM
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