Path of Pericarditis, Myocarditis, Endocarditis
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What causes 80% of Myocarditis?
Viruses. Mainly Coxsackie B Virus
What cells are involved with Fibrinous Pericarditis?
What invades the Myocardium in Viral Myocarditis and what does it secrete?
- T Lymphocytes.
- Secretes lymphokines like Interleukins and TNF
What is the pathology of Viral Myocarditis?
- Pale and congested areas w/ mild hypertrophy.
- Biventricular dilatation and generalized hypokinesis of the myocardium
- Tiger Effect
- Hearts are usually flabby and dilated
What are the vegetations of Infective Endocarditis like?
Composed of thrombi and bacteria, which can embolize, causing septic infarcts or abscesses
What is the vast majority of infective endocarditis composed of?
What usually causes Acute Bacterial Endocarditis (ABE)?
Staph Aureus or Gram Negatives
What kind of infection is Acute Bacterial Endocarditis (ABE)?
Highly destructive infection of the valves usually of a normal heart valve
What usually causes endocarditis of previously damaged native heart valves or otherwise abnormal valves?
Aplha-hemolytic Strept (Strep viridans)
What usually causes endocarditis of normal heart valves and sometimes prosthetic heart valves?
Virulent Staph species (aureus)
Major offender in IV drug abusers?
What causes the majority of prosthetic valve endocarditis?
What is the gross presentation of infective endocarditis like?
Vegetations are large, bulky, and friable which contain fibrin, thrombin, inflammatory cells, and "Bacteria" most commonly on the Mitral and Aortic valves
Characteristics of Fungal Endocarditis
Larger than bacterial vegetations and are more commonly seen on the tricuspid valve
What is the most consistent clinical feature of Endocarditis?
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