Pharm for Endocarditis

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What is the spectrum of activity for Aminoglycosides?
- Aerobic - Oxygen dependent process
- Gr- Bacteria
What are the adverse reactions for Aminoglycosides?
- Nephrotoxicity
- Ototoxicity - hearing loss
- NM Blockade
What is the MOA for Aminoglycosides?

Irreversible inhibitors of protein synthesis