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daynuhmay
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arrest of bleeding or clot formation following vascular injury
hemostasis
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normal platelet count
150,000-400,000/mm3
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thrombocytosis
plt count >400,000/mm3
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3 key players in hemostasis
- 1) platelets
- 2) coagulation cascade
- 3) blood vessels
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3 steps of platelet plug formation
- 1) adhesion
- 2) activation
- 3) aggregation
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5 steps of hemostasis
- 1) vascular constriction
- 2) platelet plug formation
- 3) clotting cascade activation
- 4) blood clot formation
- 5) clot dissolution
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Vitamin K dependent factors (6)
- 1) II
- 2) VII
- 3) IX
- 4) X
- 5) protein C
- 6) protein S
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forms plasmin from plasminogen; secreted by endothelial cells; important vascular activator
tissue plasminogen activator (tPA)
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