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PHRD5015 Lecture 27 - Hemostasis & Thrombosis
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arrest of bleeding or clot formation following vascular injury
hemostasis
normal platelet count
150,000-400,000/mm
3
thrombocytosis
plt count >400,000/mm
3
t
1/2
of plts
10 days
3 key players in hemostasis
1) platelets
2) coagulation cascade
3) blood vessels
3 steps of platelet plug formation
1) adhesion
2) activation
3) aggregation
5 steps of hemostasis
1) vascular constriction
2) platelet plug formation
3) clotting cascade activation
4) blood clot formation
5) clot dissolution
Vitamin K dependent factors (6)
1) II
2) VII
3) IX
4) X
5) protein C
6) protein S
forms plasmin from plasminogen; secreted by endothelial cells; important vascular activator
tissue plasminogen activator (tPA)
Author
daynuhmay
ID
252562
Card Set
PHRD5015 Lecture 27 - Hemostasis & Thrombosis
Description
Hemostasis & Thrombosis
Updated
12/11/2013, 11:46:43 AM
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