PHRD5015 Lecture 27 - Hemostasis & Thrombosis

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arrest of bleeding or clot formation following vascular injury

hemostasis
normal platelet count

150,000-400,000/mm³
thrombocytosis

plt count >400,000/mm³
t_1/2 of plts

10 days
3 key players in hemostasis
- 1) platelets
- 2) coagulation cascade
- 3) blood vessels
3 steps of platelet plug formation
- 1) adhesion
- 2) activation
- 3) aggregation
5 steps of hemostasis
- 1) vascular constriction
- 2) platelet plug formation
- 3) clotting cascade activation
- 4) blood clot formation
- 5) clot dissolution
Vitamin K dependent factors (6)
- 1) II
- 2) VII
- 3) IX
- 4) X
- 5) protein C
- 6) protein S
forms plasmin from plasminogen; secreted by endothelial cells; important vascular activator

tissue plasminogen activator (tPA)

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252562

Card Set

PHRD5015 Lecture 27 - Hemostasis & Thrombosis

Description

Hemostasis & Thrombosis

Updated

2013-12-11T11:46:43Z

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