PHRD5015 Lecture 27 - Hemostasis & Thrombosis

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daynuhmay
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252562
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PHRD5015 Lecture 27 - Hemostasis & Thrombosis
Updated:
2013-12-11 06:46:43
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Hemostasis Thrombosis
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Hemostasis & Thrombosis
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  1. arrest of bleeding or clot formation following vascular injury
    hemostasis
  2. normal platelet count
    150,000-400,000/mm3
  3. thrombocytosis
    plt count >400,000/mm3
  4. t1/2 of plts
    10 days
  5. 3 key players in hemostasis
    • 1) platelets
    • 2) coagulation cascade
    • 3) blood vessels
  6. 3 steps of platelet plug formation
    • 1) adhesion
    • 2) activation
    • 3) aggregation
  7. 5 steps of hemostasis
    • 1) vascular constriction
    • 2) platelet plug formation
    • 3) clotting cascade activation
    • 4) blood clot formation
    • 5) clot dissolution
  8. Vitamin K dependent factors (6)
    • 1) II
    • 2) VII
    • 3) IX
    • 4) X
    • 5) protein C
    • 6) protein S
  9. forms plasmin from plasminogen; secreted by endothelial cells; important vascular activator
    tissue plasminogen activator (tPA)

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