oncology other badness

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Author:
coal
ID:
252698
Filename:
oncology other badness
Updated:
2013-12-11 20:57:03
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oncology other badness
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Description:
oncology other badness
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  1. antidote for extrav in anthracyclines
    dexrazoxane - totect
  2. antidote for extravas for cisplatin & mechlorethamine
    sodium thiosulfate
  3. antidote for extravas for taxanes & vinca alkaloids
    hyaluronidase
  4. tx for extravas for taxanes and other non specific
    cold copress
  5. tx for etoposide, tonepiside & vinca alkaloids
    heat compress
  6. tx for high emetic high risk
    5HT3 + steroid + steroid + NK-1 antagonist
  7. tx of moderate emetic risk
    • day 1 5 HT3 + steroid
    • day 2-3 5-HT3 monotherapy, steroid monotherpy, or NK1 + steroid, lorazepam, H2 blocker or PPI
  8. big offenders of extravasiation
    • dactinomycin
    • anthracyclines
    • mitoxantrone
    • vinca
    • oxaliplatin
    • paclitaxel
    • epipodophyllotoxine
    • mechlorethamine
    • cisplatin
  9. lab values for TLS
    • hyperkalemia
    • hyperuricemia
    • hyperphosphatemis
    • hypocalcemia
  10. 2 of the 3 criteria to diagnose TLS
    • ARF (rise in Scr to 1.5 x ULN)
    • arrhythmias
    • seizures
  11. lab diagnosis of TLS values
    • potassium >6
    • phosphorus >6.5
    • calcium < 7
    • uric acid > 8

    or a 25% increase from baseline
  12. hand foot skin reaction for grade 1
    urea 20% + clobetasol 0.05%
  13. hand foot skin reaction tx for grade 2
    urea 20% BID + clobetasol 0.05% + pain control
  14. hand foot skin reaction tx for grade 3
    stop tx until grade 0-1 then continue with clobetasol 0.05 % + pain control
  15. big offenders with dermatologic toxicity
    • sorafenib - papulopustual
    • sunitinib
  16. tx of dermatologic toxicities
    hydrocortisone, clindamycin, stop cancer tx when get to stage 3 and add prednisone 0.5 mg/kg x 5 days

    prophylaxis= doxycycline or minocycline + LD topical steroid
  17. paronychia tx grade 1
    continue agent, topical antibiotics & vinegar soaks
  18. paronychia tx for grade 2
    same as 1 but add silver nitrate
  19. paronychia tx grade 3
    systemic antibiotic, weekly silver nitrate, maybe nail avulsion

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