Antiviral

Card Set Information

Author:
alvo2234
ID:
252756
Filename:
Antiviral
Updated:
2013-12-12 01:28:45
Tags:
Dr Guzman
Folders:
PT,IV,final
Description:
final
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user alvo2234 on FreezingBlue Flashcards. What would you like to do?


  1. types of symmetry of the virus capsid
    • helical
    • icosahedral 
    • spherical
  2. transmission for nonenveloped virus
    fecal-oral route
  3. stability of enveloped and nonenveloped viruses
    • enveloped viruses are environmentally labile
    • unenveloped viruses are environmentally stable
  4. transmission for enveloped viruses
    • respiratory 
    • sexual
    • parenteral
  5. what are the first line of defense against viruses
    natural barriers (i.e. skin, mucus)
  6. what are the host responses to viral infections
    • natural barriers 
    • induced barriers 
    • humoral components (INF, cytokines)
    • antigen-specific response
    • cellular components
  7. therapeutic uses of INF alpha and beta
    • Hep B
    • Hep C
    • herpes zoster
    • papilloma virus
    • rhino virus
    • warts
  8. types of acute viral infections
    • respiratory 
    • GI (rotavirus, norovirus)
  9. types of persistent viruses
    • measles
    • rubella
  10. types of latent viruses
    HSV-1,2 and VZV
  11. types of chronic viruses
    HIV
  12. antivirals that affect attachment
    • oseltamivir
    • zanamivir
  13. antivirals that affect the penetration and uncoating
    • amantidine
    • rimantidine
  14. antivirals that inhibit viral replication
    • acyclovir, valacyclovir
    • ganciclovir, valganciclovir
    • foscarnet 
    • cidofovir
    • penciclovir
  15. alphaherpesviridae
    • HSV-1
    • HSV-2
    • VZV
  16. betaherpesviridae
    CMV
  17. gammaherpesviridae
    epstein barr virus
  18. what is the most common viral sporatic viral infection of CNS
    HSV encephalitism (HSV-2)
  19. acyclovir is activated by which enzyme
    thymidine kinase
  20. what does acyclovir compete with
    deoxyguanosine triPO4
  21. acyclovir main elimination
    renal
  22. valtrex relation to acyclovir
    it is a L-valyl ester prodrug which is rapidly converted to acyclovir
  23. preparations of acyclovir
    • oral 
    • parenteral
    • topical
  24. preparations of valtrex
    oral
  25. preparations for famciclovir
    oral (tablets, film coated)
  26. primary tx for genital HSV
    • acyclovir 
    • famciclovir
    • valacyclovir
  27. tx for HSV encephalopathy/meningitis
    acyclovir IV
  28. how is acyclovir IV dosed for HSV enceph/meningitis
    • with actual body weight
    • 10/mg/kg q8hrs x 10 days
  29. VZV vaccines available
    • Varivax- single antigen
    • Pro Quad- combination
  30. VZV postexposure prophylaxis exposure vaccine
    VariZIG
  31. CMV primary infection is mainly seen in these pts
    immunocompromised persons
  32. CMV nucleoside antivirals
    • ganciclovir
    • valganciclovir
    • cidofovir
  33. CMV non-nucleoside analogs
    foscarnet
  34. valganciclovir preparation
    PO only
  35. valganciclovir primary use
    • CMV prevention in transplant and HIV
    • CMV retinitis
  36. MOA of foscarnet
    selectively inhibits pyrophosphate bonding on virus specific DNA polymerases
  37. antivirals which bioavailabilty increase with food
    gan/valganciclovir
  38. black box warnings for foscarnet and cidofovir
    avoid other nephrotoxins
  39. which antiviral should be avoided in renal impairment
  40. cidofovir
  41. agents used to tx EBV
    • antivirals ineffective
    • corticosteroids my be considered for mononucleosis
  42. family of flu virus
    orthomyxoviridae
  43. Flu key glycoproteins used during infection of host cell
    • haemagglutinin
    • neuraminidase

What would you like to do?

Home > Flashcards > Print Preview