Pharm FMS III

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Author:
Anonymous
ID:
253185
Filename:
Pharm FMS III
Updated:
2013-12-14 20:09:41
Tags:
drugs
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Description:
Antiomicrobials, Antineoplastic, AntiViral, AntiFunal, AntiAmoebic
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  1. Penicillin G + V
    • Antimicrobial
    • Cell Wall Synthesis Inhibitor
    • Streptococcus, Meningococcus
  2. Amoxicillin
    • Antimicrobial
    • Cell wall Synthesis Inhibitor - Penicillin
    • Used vs Otitis Media
    • Combine with clauvanate (B lact inhibitor)
  3. Ampicillin
    • Antimicrobial
    • Cell wall Synthesis Inhibitor - Penicillin
    • Used vs meningitis
    • Combine with sulbactam (B Lact inhibitor)
  4. Piperacillin / Ticarcillin
    • Antimicrobial
    • Cell wall Synthesis Inhibitor - Penicillin
    • Antipsuedomonal
  5. Nafcillin / Dicloxacillin
    • Antimicrobial
    • Cell wall Synthesis Inhibitor - Penicillin
    • B Lact Resistant
    • used for osteomyelitis/ cellulitis
  6. Vancomycin
    • Antimicrobial
    • Cell wall synthesis inhibitor
    • Use on MRSA and patients allergic to penicillins
    • Binds acyl-D-ala-D-ala
    • Adverse Effects: Red man syndrome, ototoxicity, nephrotoxicity
  7. Cefazolin
    • Antimicrobial
    • Cell wall Synthesis Inhibitor - Cephalosporin
    • use: prophylaxis for Staph Aureus
  8. Cefprozil
    • Antimicrobial
    • Cell wall synthesis inhibitor - Cephalosporin
    • Use: otitis media when due to H Influenza
  9. Ceftriaxone/Cefotaxime
    • Antimicrobial
    • Cell Wall synthesis inhibitor - cephalosporin
    • Use: Gonorrhea + Meningitis
  10. Gentamicin / Neomycin
    • Protein Synthesis Inhibitors
    • Aminoglycoside
    • Bind 30S, no initiation
    • Use: staph , enterococcus
    • Adverse: Renal Toxicity, ototoxicity
  11. Tetracycline / Doxycycline
    • Protein Synthesis Inhibitors
    • Bind 30S, no addition
    • Use: Ricketsia, Lyme Disease
    • Adverse Effects: bind to bone
    • Absorption decreases if metals/milk ingested
    • CI: < 8yo, pregnant, nursing
  12. Erythromycin / Azithromycin
    • Protein Synthesis Inhibitors
    • Macrolides
    • Bind 50S, no A-->P
    • Use: Pneumonia
    • CI: Liver failure
    • replace with doxycycline
  13. Clindamycin
    • Protein Synthesis Inhibitor
    • Binds 50S, no translocation
    • Use: Penicillin Resistance Strep
    • Adverse: Pseudomembranous Collitis
  14. Sulfamethoxazole
    Inhydrophosphate Synthase

    • Use: UTI with TMP+SMX
    • Adverse Effects: Steven's/Johnson
    • Kerniticus in neonates
    • CI: <3 months old, nursing, pregnant
  15. Trimethoprim
    • Inhibits dihdrofolate reductase
    • Adverse Effects: Renal Insuffiency
    • TMP + SMX for UTI
  16. Ciprofloxacin / Levofloxacin
    • Fluroquinalone
    • Inhibit DNA Gyrase
    • Use: UTI, Traveler's Diarrhea, pneumonia
    • Adverse: CNS effects
    • CI: Epileptic Patients
    • Chelates metals
  17. Isoniazid
    • Inhibits mycolic Acid
    • Use: TB, prophylaxis
    • Adverse: Hepatitis
    • CI: Liver failure
  18. Rifampin
    • Binds B subunit of RNA polymerase
    • Use: TB, prophylaxis
    • Adverse: Hepatitis
    • CI: Liver failure
  19. Ethambutol
    • Blocks Arabinosyl transferase
    • Use: TB
    • Adverse: Optic neuritis, acute gout
  20. Mechlorethamine
    • Nitrogen Mustard
    • Reacts with 7-N Guanine residue in DNA. Causes inter/intra crosslinking
    • Highly Toxic, used for Hodgkins
  21. Cyclophosphamide
    • Antineoplastic - Alkylating Agents
    • Nitrogen Mustard
    • Reacts with 7-N Guanine residue in DNA. Causes inter/intra crosslinking
    • Hepatic CYP-450 hydoxylates to Aldophosphamide. Breaks down into phosphamide (active) and Acrolein (toxic)
    • Use: Broad Spectrum
    • Toxicity: Hemorrhagic Cystitis
    • Decrease dose if taking with allopurinol
  22. Nitrosoureas
    • Antineoplastic - Alkylating Agents
    • Alkylate DNA
    • Carbomoylates
    • Carmustine, Losmustine, Semustine
    • delayed myelosuppresion
    • Streptozoticin
    • Diabetogenic
  23. Cisplatin / Carboplatin
    • Antineoplastic - Alkylating Agents
    • Platinum Compounds
    • React with guanine residues
    • Active cis form
    • Cisplatin:
    • nephrotoxicity, ototoxity
    • use if immune compromised
    • Carboplatin
    • delayed myelosuppresion
    • Use if renal dysfunction
  24. Procarbazine
    • Antineoplastic - Alkylating Agents
    • tMethylating Agent
    • Weak Mao inhibitor
    • Converted by hepatic CYP 450
    • Use: Hodgkins, Small Cell
    • Adverse: don't use with sympathomimatic drugs or sedatives
  25. Methotrexate
    • Antineoplastic - Antimetabolite
    • S Phase specific
    • Folate Antognist
    • Direct competition on dihydrofolate reductase to indirectly inhibit DNA synthesis
    • Enters cells non-specifically, use leuvocorin to protect tissue
  26. 5-Fluorouracil / 5-Fluorodeoxyuridine
    • Antineoplastic - Antimetabolite
    • S Phase specific
    • Pyrimidine Antagonist
    • Incorporate into RNA
    • Use: GI, breast, head and neck, keratosis of skin

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