What is increased in terms of mitochondrial DNA in autistic children? What is decreased?
mtDNA replication and mtDNA deletions.
low NADH oxidase activity, low succinate oxidase activity (this leads to lactate:pyruvate ratio of 6, compared to 12 for controls and implies NAD:NADH ratio of 1500:1, as opposed to 750:1 for controls)
Increased H2O2 production in lymphocytic mitochondria (Complex 1 and complex 2)