N2: Cys Loop Receptors
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Cryo-EM structure of Torpedo nAChR at 9Å
Cryo-EM structure of Torpedo nAChR at 4Å
Dougherty's group, 1998
Fluorinated tryptophan on B loop cannot bind ACh. Implicates cation-pi.
Brejc et al., 2001
Structure of AChBP.
Calf-Torpedo nAChR chimeras' conductance determined by M2
Kelley et al., 2003
5HT3A-B nAChR chimeras' conductance determined by M3-4 loop/intracellular domain
Cryo-EM of ACh-activated/ferritin-labelled Torpedo nAChR shows displacement of β and straightening of αγ and δ M2s to open pore
Hilf & Dutzler, 2008
Structure of Erwinia chrysanthemi pentameric ligand gated ion channel (ELIC) at 3.3Å.
Bocquet et al, 2009
Structure of Gloeobacter violaceus ligand gated ion channel (GLIC) at 2.9Å.
Hibbs & Gouaux, 2011
Structure of C. elegans GluCl at 3.3Å, in the presence of ivermectin
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