pharm psych & hormones

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shmvii
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253904
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pharm psych & hormones
Updated:
2013-12-19 18:54:39
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pharm
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  1. hypnotics treat what?
    sleep disorders
  2. anxiolytics treat what?
    anxiety
  3. hypnotics and anxiolytics are mostly from what groups?
    • serotonine agonists
    • benzodiazapenes 

    (diazepan, from the same group, treats SZ by potentiating GABA's inhib effect)
  4. benzodiazapenes treat anxiety and sleep disorders how? (real basic)
    enhance GABA mediated inhibition in the CNS
  5. neuroleptics - treat what?
    psychosis, schizo, esp auditory hallucinations, behavioral disturbances
  6. neuroleptics - basic mechanism/type of drug
    dopamine receptor antagonist
  7. two mechanisms for anti-depressants
    inhibit uptake of noradrenaline & serotonine

    inhibit monomine oxidase
  8. imipramine - type of drug? use?
    • tri-cyclic
    • antidepressant
  9. a drug that inhibits uptake of serotonine and noradrenaline
    imipramine - it's a tri-cyclic antidepressant
  10. mineralocorticoides - type of corticosteroid released by adrenal cortex -- the main one? the main activity?
    • aldosterone
    • salt retention
  11. glucocorticoides - type of corticosteroid released by adrenal cortex -- the main one? the 2 main activities?
    • cortisol
    • affect carb and protein metabolism,
    • suppress inflam, allergies, immune responses
  12. 3 glucocorticoids (an cortisol is a 4th? or the below are variations of cortisol?)
    • Hydrocortisone,
    • Prednisolone,
    • Dexamethasone
  13. hydrocortisone, prednisolone, dexamethasone -- type of hormone? what metabolic effect?
    glucocorticoid

    stim gluconeogenesis, increase blood glucose --> insulin release
  14. hydrocortisone, prednisolone, dexamethasone -- type of hormone? what anti-inflam effect?
    glucocorticoid

    inhibit formation of pro-inflam mediators (prostaglandins & leukotrienes)
  15. hydrocortisone, prednisolone, dexamethasone -- type of hormone? what immunosuppresive effect?
    glucocorticoid

    • inhibit T & B lymphocyte function
    • decrease macrophages and lymphoctes
  16. sulphonylure
    oral anti-diabetic -- stronger than tolbutamide
  17. tolbutamide
    oral anti-diabetic -- weaker than sulphonylure
  18. insulin preparations - short, med, long
    • short acting up to 7 h,
    • medium acting up to 22h - semilente and lente mixture with zinc,
    • long acting up to 36h - ultralente 
    • mixture with insoluble zinc crystals
  19. thyroid gland secretes T3 &T4 -names?

    responsible for what?
    • T3 = triiodothyronine
    • T4 = thyroxin

    •  optimal growth, development, function and maintenance of
    • body tissues
  20. calcitonin - produced where? regulates what?
    • parafollicular cells
    • calcium metabolism
  21. synthesis of T3 (triiodothyronine) and T4 (thyroxin) requires what?
    iodine
  22. Grave's disease = hyperthyroidism -- treated with __ and __
    • thionamides
    • propranolol
  23. thianomides - treats what? how?
    • treats graves/hyperthyroidism
    • block process of organification (iodine reacting w tyrosine to form...)
  24. propranolol - treats what _ _ _
    • hyperthyroidsm/grave's
    • HTN
    • high HR
  25. hypothyroidism aka
    myxoedema
  26. 2 drugs to treat hypothyroidism aka myxoedema
    • thyroxine (T3)
    • liothyronine (oral) (sodium salt of T4)

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