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What sort of cells can common lymphoid progenitors become?
T Cells; B Cells; NK cells
What Cluster of Differentiation (CD) proteins do Pro-B and Pre B-1 cells have
CD 10; CD 34
They then develop characteristic CD__ and CD __ markers.
CD 19; CD 20
What does VDJ stand for? How many genes each? Ig heavy of light ?
Variable (50); Diversity (25); Junction (6)
Which is spliced first VD or DJ? Which proteins control it?
DJ controlled by RAG1 and RAG2
How are nave B cells screened for auto reactivity (3 methods)?
High xlinking with self; Minimal xlinking (anergy); Receptor editing (40-50% rearrange another light chain)
Where do nave B-Cells move to ? What do they need for further differentiation?
Spleen; LN; MALT; GALT; Need Ag and Tcell help
IL __ causes T cells to be creased from common lymphoid progenitors ?
Where do T cells migrate to initially? What is a double positive thymocyte ?
Thymus in the cortex; common thymocytes express CD4 and CD8
What is the structure of athe TCR? What is CD3?
Tcell a1a2:b1b2; CD3 g1e1 d1e1
What is the VDJ segment of chain similar to? Does alpha; beta; gamma or delta have 2 common regions?
Undergo VDJ similar to Ig; Beta has 2 constant regions
CD4 cells are called ____ while CD8 cells become ____ !
CD4 Thelper and CD8 Cytotoxic Tcell
Which TCR chain rearranges fist ? Which has VDJ vs VJ ?
"Beta rearranged first; b=VDJ
Next T cells undergo positive and negative selection! What is this ?
Positive=Only Tcells which interact MHC are kept; Negative=Tcells with increased increased affinitiy for self are deleted or become Treg celss
In the thymus medullary epitherial cells the ____ gene is epressed to expose self antigens
What is autosomal recessive AIRE defiency called
APECED - Autoimmune PolyEndocrinopathy with Candidiasis and Ectodermal Dystrophy
Prep cards for immunology