Naloxone Hydrochloride (Narcan)

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Naloxone Hydrochloride (Narcan)
2010-07-01 17:11:53

Paramedic Pharmacology
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  1. Naloxone Hydrochloride (Narcan)
    Narcotic Antagonist
  2. Naloxone Hydrochloride (Narcan)
    Mechanism of Action
    Competitive inhibition at narcotic receptor sites, reverse respiratory depression secondary to depressant drugs, completely inhibits the effect of morphine.
  3. Naloxone Hydrochloride (Narcan)
    Opiate overdose, coma; complete or partial reversal of CNS and respiratory depression induced by opioids; decreased level of consciousness; coma of unknown origin; narcotic agonist for the following: Morphine, Heroin, hydromorphone (Dilaudid), methadone, meperidine (Demerol), paregoric, fentanyl (Sublimase), oxycodone (Percodan), codeine, propoxyphene (Darvon); narcotic agonist and antagonist for the following: Butorphanol (Stadol), pentazocine (Talwin), nalbuphine (Nubain).
  4. Naloxone Hydrochloride (Narcan)
    Use with caution in narcotic-dependent patients; use with caution in neonates of narcotic-addicted mothers.
  5. Naloxone Hydrochloride (Narcan)
    Adverse Reactions
    Withdrawal symptoms in the addicted Pt., tachycardia, hypertension, arrhythmias, nausea, vomiting, diaphoresis.
  6. Naloxone Hydrochloride (Narcan)
    Drug interactions
    Incompatible with bisulfite and alkaline solutions.
  7. Naloxone Hydrochloride (Narcan)
    How supplied
    0.02 mg/mL (neonate); 0.4mg/mL, 1mg/mL; 2.0mg/5mL ampules; 2mg/5mL prefilled syringe.
  8. Naloxone Hydrochloride (Narcan)
    Dosage and administration
    • Adult: 0.4-2.0mg IV, IM, SC, or ET (diluted); minimum recommended dose, 2.0mg; repeat at 5 minute intervals to a maximum dose of 10mg (medical control may request higher amounts). Infusion: 2mg in 500mL of D5W (4mcg/mL), infuse at 0.4mg/h (100mL/h).
    • Pediatric: 0.1mg/kg/dose IV, IM, SC, ET (diluted); maximum dose of 0.8mg; if no response in 10 minutes, administer and additional 0.1mg/kg/dose.
  9. Naloxone Hydrochloride (Narcan)
    Duration of action
    • Onset: within 2 minutes.
    • Peak effect: variable.
    • Duration: 30-60 minutes.
  10. Naloxone Hydrochloride (Narcan)
    Special Considerations
    Pregnancy safety: Category B. Seizures without causal relationship have been reported. May not reverse hypotension. Use caution when administering to narcotic addicts (potential violent behavior).