Tumor Suppressor Genes

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Author:
xangxelax
ID:
255258
Filename:
Tumor Suppressor Genes
Updated:
2014-01-05 22:15:13
Tags:
Board Prep
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  1. Gene: Rb
    • Associated Tumor: Retinoblastoma, osteosarcoma
    • Gene Product: Inhibits E2F; blocks GI --> S phase
  2. Gene: p53
    • Associated Tumor: Most human cancers, Li-Fraumeni syndrome
    • Gene Product: Transcription factor for p21, blocks G1 --> S Phase
  3. Gene: BRCA1
    • Associated Tumor: Breast and Ovarian Cancer
    • Gene Product: DNA repair protein
  4. Gene: BRCA2
    • Associated Tumor: Breast and Ovarian Cancer
    • Gene Product: DNA repair protein
  5. Gene: p16
    • Associated Tumor: Melanoma
    • Gene Product: --
  6. Gene: BRAF
    • Associated Tumor: Melanoma
    • Gene Product: B-raf
  7. Gene: APC
    • Associated Tumor: Colorectal cancer (associated w/ FAP)
    • Gene Product: --
  8. Gene: WT1
    • Associated Tumor: Wilms' Tumor (nephtoblastoma)
    • Gene Product: --
  9. Gene: NF1
    • Associated Tumor: NeuroFibromatosis type 1
    • Gene Product: RAS GTPase activating protein (RAS-GAP)
  10. Gene: NF2
    • Associated Tumor: NeuroFibromatosis type 2
    • Gene Product: Merlin (schwannomin) protein
  11. Gene: DPC4
    • Associated Tumor: Pancreatic Cancer
    • Gene Product: DPC-Deleted in Pancreatic Cancer
  12. Gene: DCC
    • Associated Tumor: Colon Cancer
    • Gene Product: DCC-Deleted in Colon Cancer

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