Persistent higher P (pressure) leads to higher T (wall tension) that is first normalized by increases mostly in h (wall thickness).
Note: The heart will always try to keep wall tension (T) normalized.
This is compensated pathologic hypertrophy
Eventually, the myocytes can’t meet the demand and the heart fails.
- Some myocytes are replaced by fibrosis reducing T, P & h while r increases. This is
- decompensated, dilated hypertrophy & heart failure.