2.2 Cholesterol and Bile Acid Metabolism

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Author:
xangxelax
ID:
256372
Filename:
2.2 Cholesterol and Bile Acid Metabolism
Updated:
2014-01-14 01:42:00
Tags:
CP2
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CP2
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CP2
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  1. #1 Drug to treat Heart disease?
    Statins
  2. How do human cells obtain cholesterol?
    • Biosynthesis - synthesized w/in the cell
    • Endocytosis of lipoproteins - LDL's deliver cholesterol by binding to the LDL receptor through apo B100
  3. What do Statins do?
    Inhibit cholesterol synthesis in all cells
  4. During endocytosis, what binds to the LDL receptor?
    Apolipoprotein B100
  5. During endocytosis, what does apolipoprotein B100 bind to?
    LDL receptor
  6. What does mutations of either apo B100 or the LDL receptor do and what is this called?
    • Prevent binding of LDLs to cells
    • Familial Hypercholesterolemia
  7. With high blood LDL concentration, what happens to storage, biosynthesis, and uptake?
    • Down regulates synthesis
    • Down regulates production
    • Up regulates storage
  8. What is the key regulatory enzyme in cholesterol biosynthesis?
    HMG CoA reductase
  9. What effect does insulin have on cholesterol?
    It up regulates it
  10. How does statins inhibit cholesterol biosynthesis?
    • Statins mimic HMG CoA
    • HMG CoA reductase is inhibited by statins and does it by mimicry
  11. What are side effects of statins?
    Myopathies (muscle pain)

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