2.3 Introduction to Coagulation Part 2 (Formation of the Fibrin Clot)

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xangxelax
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2.3 Introduction to Coagulation Part 2 (Formation of the Fibrin Clot)
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2014-01-14 13:58:02
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  1. What does the liver need to make circulating coagulation system elements?
    Vitamin K
  2. Where are the circulating coagulation system elements made?
    Liver
  3. Are the circulating coagulation system elements in an active or inactive form when circulating?
    Inactive
  4. What is the key step needed in making a precursor of Vit. K dependent clotting factor (glutamic acid) into Vit. K dependent clotting factor?
    Carboxylation of glutamic acid residues
  5. What is an important step in the vitamin K dependent clotting factors?
    Gamma carboxyl binding to Ca2+ which binds to phosopholipid membranes
  6. What are the Vitamin K Dependent Coagulation clotting factors made in the liver?
    • Prothrombin (Factor II)
    • VII
    • IX
    • X
  7. What are the Vitamin K Dependent Coagulation Natural anticoagulants made in the liver?
    • Protein C
    • Protein S
  8. What activates the extrinsic coagulation pathway?
    Exposure of blood to subendothelial TISSUE FACTOR
  9. What activates the intrinsic coagulation pathway?
    Exposure of blood to subendothelial COLLAGEN
  10. What is the purpose of fibrin strands?
    Cements platelet plug into place
  11. What is Factor 1 called?
    Fibrinogen
  12. What is Factor 2 called?
    Prothrombin
  13. What is Factor 3 called?
    Tissue Factor
  14. Which factor is Fibrinogen?
    Factor 1
  15. Which factor is Prothrombin?
    Factor 2
  16. Which factor is Tissue Factor?
    Factor 3
  17. Which factor is Thrombin?
    Factor 2a
  18. What is Factor 2a called?
    Thrombin
  19. What is the common endpoint of the intrinsic and extrinsic coagulation pathway?
    Factor 10a
  20. What are the roles of Thrombin?
    • Converts 5 --> 5a
    • Converts 7 --> 7a
    • Converts 8 --> 8a
    • Converts 13 -- > 13a
    • Converts Fibrinogen --> Fibrin
  21. What is the coagulation test used to test for the intrinsic pathway?
    aPTT (activated partial thromboplastin time (secs))
  22. What is the coagulation test used to test for the extrinsic pathway?
    • PT (prothrombin time)
    • Measured in seconds
  23. What tests for Warfarin?
    PT
  24. What tests for Hepararin?
    aPTT
  25. What does APC (Activated Protein C) inactivate?
    • Factor 5a
    • Factor 8a
  26. What activates Protein C?
    Thrombomodulin
  27. What are the 6 ways that blood clotting is controlled and/ or inhibited?
    • Tissue Factor
    • Localization due to phospholipid membrane
    • Inhibitor pathway
    • Protein C pathway
    • Antithrombin
    • Fibrinolysis being activated

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