2.3 Introduction to Coagulation Part 2 (Formation of the Fibrin Clot)
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What does the liver need to make circulating coagulation system elements?
Where are the circulating coagulation system elements made?
Are the circulating coagulation system elements in an active or inactive form when circulating?
What is the key step needed in making a precursor of Vit. K dependent clotting factor (glutamic acid) into Vit. K dependent clotting factor?
Carboxylation of glutamic acid residues
What is an important step in the vitamin K dependent clotting factors?
Gamma carboxyl binding to Ca2+ which binds to phosopholipid membranes
What are the Vitamin K Dependent Coagulation clotting factors made in the liver?
- Prothrombin (Factor II)
What are the Vitamin K Dependent Coagulation Natural anticoagulants made in the liver?
What activates the extrinsic coagulation pathway?
Exposure of blood to subendothelial TISSUE FACTOR
What activates the intrinsic coagulation pathway?
Exposure of blood to subendothelial COLLAGEN
What is the purpose of fibrin strands?
Cements platelet plug into place
What is Factor 1 called?
What is Factor 2 called?
What is Factor 3 called?
Which factor is Fibrinogen?
Which factor is Prothrombin?
Which factor is Tissue Factor?
Which factor is Thrombin?
What is Factor 2a called?
What is the common endpoint of the intrinsic and extrinsic coagulation pathway?
What are the roles of Thrombin?
- Converts 5 --> 5a
- Converts 7 --> 7a
- Converts 8 --> 8a
- Converts 13 -- > 13a
- Converts Fibrinogen --> Fibrin
What is the coagulation test used to test for the intrinsic pathway?
aPTT (activated partial thromboplastin time (secs))
What is the coagulation test used to test for the extrinsic pathway?
- PT (prothrombin time)
- Measured in seconds
What tests for Warfarin?
What tests for Hepararin?
What does APC (Activated Protein C) inactivate?
What activates Protein C?
What are the 6 ways that blood clotting is controlled and/ or inhibited?
- Tissue Factor
- Localization due to phospholipid membrane
- Inhibitor pathway
- Protein C pathway
- Fibrinolysis being activated
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