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xangxelax
on FreezingBlue Flashcards.
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What are macrophages filled with fat called?
Foam Cells
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What are foam cells?
Macrophages filled with fat
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What 2 diseases are intimally related to atheroscerlosis?
- Diabetes (metabolic derangement)
- Hypertension (physical force)
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What is the major complication of the atheroma?
- Hardening of the vessel
- Consequence of calcification, precipitated by local tissue degeneration
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What are the 2 major complications of atheromas?
- Aneurysm formation
- Thrombi formation causing embolism
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What is the most feared complication of Aortic Aneurysms?
Rupture and death by exsanguination
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What material is the artificial vessel used to replace an aneurysm made of?
Dacron or Gortex material
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What are the biggest reasons for Dissecting Ascending Aortic Aneurysms?
- 1. Hypertension
- 2. Marfans
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Atherosclerosis affects the lower or upper extremities more?
Legs more
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What is an endarterectomy?
Surgical intervention involving the removal of plaque
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What do the coronaries in coronary artery disease look like?
Rigid, heavily calcified cylinders that can be palpated beneath the epicardium
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What do the lumina look like in coronary artery disease?
Narrowed due to prominent fibrotic plaques and atheromas
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What do the walls of coronary arteries contain in coronary artery disease?
Deposits of calcium salts and cholesterol clefts
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What is the cause of Sudden Cardiac Death?
- Consequence of a major cardiac arrhythmia (ie. V-fib) or later complete heart block and pump failure
- Happens in 1/4 of ppl that have MI
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What are the 2 organs that are the most susceptible to anoxia?
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Where is the infarction for the Subendocardial or Intramural MI?
- Concentric around the subendocardial layer of the left ventricle
- All of endocardium and 1/2 of myocardium involved
- (Other 1/2 of myocardium and epicardium are still viable)
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What are the initial histologic findings of an MI?
- Myocardial cell death w/ wavy, eosinophilic myocytes, coagulative necrosis, and contraction bands
- Nuclei are faint or dead
- Appearance of PMN's will predominate for the next 2 days
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Collagen + Angiogenesis =
Granulation Tissue
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