Week 2: Bacterial Metabolism

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  1. Catabolism

    - definition
    - examples
    • - degrade complex molecules to smaller molecules to release energy

    • - produce energy-storage molecules
    • i.e., ATP, GTP, NADH, FADH2

    - examples: glycolysis, TCA cycle, fermentation, etc
  2. Anabolism

    - energy used to synthesize new molecules and structures

    - use energy-storage molecules

    - examples: most biosynthesis, e.g., nucleic acid, proteins, lipopolysaccharides, peptidoglycan etc
  3. Primary Energy-storage molecules
    primary molecules, yielding energy by phosphatase

    1. Adenosine triphosphate (ATP)

         ATP  ->  ADP +  Pi + energy 

    2. Guanosine triphosphate (GTP)

        GTP  ->    GDP +  Pi  + energy
  4. what molecule is the primary energy currency of bacteria?
  5. Secondary energy-storage molecules

    ATP equivalence?
    Secondary molecules, yielding ATP from the electron transport chain (ETC)

    1. reduced nicotinamide-adenine dinucleotide (NADH)

      NADH  = 3 ATP

    2. reduced flavin adenine dinucleotide (FADH2)

      FADH2 =  2 ATP
  6. Major glucose catabolism (energy production)

    Anaerobic conditions

  7. Major glucose catabolism (energy production)

    Aerobic conditions
    • 1) Glycolysis
    • 2) ETC
    • 3) Krebs cycle
  8. Glycolysis

    - aka
    - conditions
    - end product
    - aka Embden-Meyerhof-Parnas, EMP pathway

    - occurs in both aerobic and anaerobic condition

    -End product of glycolysis: 2 pyruvate
  9. Path of Pyruvate after glycolysis:

    - aerobic condition
    - anaerobic condition
    In aerobic: TCA cycle

    In anaerobic: fermentation
  10. TCA Cycle

    - conditions
    - starting molecule
    - products produced?
    - function
    • only in aerobic condition

    pyruvate is a key molecule to enter TCA cycle

    •produces most various energy-storage molecules, e.g GTP, NADH, FADH2

    •functions as common pathway for oxidation of amino acids, fatty acids, carbohydrates
  11. ETC

    end products?
    • aerobic condition
    • -  acts as a bank that cashes out energy

    • - 3 ATP generated from 1NADH
    • - 2 ATP generated from 1 FADH2
  12. Summary of aerobic glucose catabolism:

    how many total ATP
       34 ATP (ETC)

       2 ATP (glycolysis)

    + 2 GTP (TCA cycle)

    38 ATP / mole glucose
  13. Fermentation

    end products??
    Anaerobic bacteria are less efficient at energy production than aerobic bacteria.

    • anaerobic glucose catabolism produces only 2 ATP molecule per glucose.

    •Conversion of pyruvic acid to organic acids & alcohols

    •These end-products are useful for identification of bacteria and in industrial processes.
  14. Examples of Fermentation in food
  15. Name 2 other Catabolic pathways for glucose
    • Pentose-phosphate pathway
    • – glucose to pentose bypassing glycolysis

    • Entner-Duodoroff pathway
    • - only in prokaryotic

    –glucose to pyruvate and glyceraldehyde -3 phosphate

    –mostly in obligate aerobic bacteria
  16. TCA cycle (Krebs Cycle)
    - produces key intermediates for the ultimate synthesis of:

    • amino acids
    • lipids
    • purines and pyrimidines

Card Set Information

Week 2: Bacterial Metabolism
2014-01-19 03:22:47
bacterial metabolism
micro lecture- Week 2
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