1.9 Pharmacology for Shock

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Author:
xangxelax
ID:
257474
Filename:
1.9 Pharmacology for Shock
Updated:
2014-01-20 02:33:20
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CP2
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  1. What is the MOA for Metronidazole?
    • Prodrug that needs activation in certain organisms
    • Enters cells by passive diffusion
    • Produces free radicals - bactericidal effects (interacts w/ nucleic acids causing breakage and destabilization)
  2. What is the bacterial spectrum?
    • Anaerobic Gr(-)
    • Well-absorbed orally
    • Good tissue and CNS penetration
    • Well tolerated
  3. What are 2 antibiotics indicated for initial empiric tx of intra-abdominal sepsis?
    • 3rd generation cephalosporin w/ metronidazole
    • Beta-lactam or beta-lactamase inhibitor (Piperacilian/ tazobactam)
    • Carbapenem or Moxifloxacin (Ertapenem)
  4. What are the properties and clinical applications of 0.9% NaCl IV solution?
    • Properties: 9 g of NaCl (154 mEq Na and Cl)
    • Osm = 310 mOsm
    • Clinical Applications: Preferred IV fluid for tx of hypotension
  5. What are the adrenergic receptor stimulation differences between DOPamine?
    • High Doses:
    • A1 - vasoconstricts peripheral vessels
    • B1 - increases heart rate, contracility, diastolic relaxation

    • Low doses:
    • B1 – Increases heart rate, contractility, diastolic relaxation
    • B2 – vasodilates peripheral vessels
    • D1 – low doses vasodilate renal vessels
  6. What are the adrenergic receptor stimulation differences between DOBUTamine?
    • B1 – Increases heart rate, contractility, diastolic relaxation
    • B2 – vasodilates peripheral vessels
  7. What are the pharmacological effects of IV vasopressin?
    • Vasoconstriction (a1 receptors)
    • Regulates extracellular fluid volume by affecting renal handling of water
  8. What are the possible adverse effects from a catecholamine infusion?
    • Cardiac arrhythmia
    • Can precipitate angina in pts w/ coronary artery disease (b/c increases myocardial oxygen demand)
    • H/a and tremor

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