anti inflammatories.txt

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Author:
BELISA78
ID:
25805
Filename:
anti inflammatories.txt
Updated:
2010-07-06 00:52:36
Tags:
PT anti inflammatory drugs
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Description:
review of anitinflammatory drugs
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  1. this subtance is the mediator of the inflammatory process
    Prostaglandin
  2. this enzyme aids in prostaglandin synthesis
    COX (1&2)
  3. Anti-inflammatory meds include:
    asprin

    NSAIDS

    COX-2 NSAIDS

    Glucocorticosteriods
  4. what can be done to avoid drug interactions/ adverse effects?
    Use alternate methods

    dose alterations

    use submax doses of multiple meds
  5. COX enzyme --> prostaglandin synthesis --> mediation of inflammatory process

    How does aspring work in this process?
    asprin inhibits COX therefore decreasing inflammation
  6. : pyretic
    fever
  7. Indications for asprin:
    fever: anti-pyretic

    pain: analgesic

    anti-inflammatory

    Anti-platelet: inhibits platelet COX enzyme
  8. NSAIDS is a non-selective COX inhibitor therefore inhibits both COX-1 (good) and COX-2 (bad) enzymes.

    what is the differnce between asprin and NSAIDS?
    asprin is also an anti-platelet NSAIDS are not.
  9. this anti-inflammatory drug may cause edema especially in patients with renal dysfunction and heart disease.

    COX-1 inhibition --> decreased urine output --> fluid retention and edema
    NSAIDS
  10. COX-2 inhibitors were discontinued due to fatal cardiac effects. these included:
    vioxx

    celebrex

    bextra
  11. these drugs are potent anti-inflammatories:
    cortisol/hydorcortisone

    corticosteriods
  12. these are naturally occurring anti-inflammatories from the adrenal cortex
    cortisol/hydrocortisone
  13. Indications for glucocorticosteriods:
    RA

    DJD
  14. these drugs inhibit parts of the inflam process including:

    capillary dialation

    edema formation

    leukocyte and macrophage migration to area
    glucocorticosteroids

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