3.8 Drugs for Heart Failure

Card Set Information

Author:
xangxelax
ID:
258197
Filename:
3.8 Drugs for Heart Failure
Updated:
2014-01-24 14:43:33
Tags:
CP2
Folders:
CP2
Description:
CP2
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user xangxelax on FreezingBlue Flashcards. What would you like to do?


  1. How often is Digoxin given?
    Every 24-48 hours
  2. How much per day should Digoxin be given?
    0.125 mg/day
  3. What are the ADR for Digoxin?
    • Nausea
    • Vomiting
    • Bradycardia
    • AV block
    • Other atrial and ventricular arrhythmias
  4. When using Digoxin, what will increase Cardiac ADRs?
    Low serum K+
  5. What is the antidote for Digoxin?
    Digoxin Immune FAB (Digibind)
  6. What other drug should you be careful about when giving Digoxin and why?
    • Diuretics
    • Kidneys will excrete K and Na which can cause a Hypokalemia which will affect Digoxin and may cause adverse cardiac effects
  7. What is the MOA for Digoxin?
    • Inhibits Na-K ATPase Pump
    • ↑ Na+ intracellularly which prevents Na/Ca exchanger from working
    • ↑ Ca2+ intracellularly = ↑ myocyte contractions
    • Affects AV nodal conduction = ↓ HR
  8. How is Digoxin eliminated?
    Primarily renal elimination
  9. What drugs affect AV node?
    • Class II - B-blocker
    • Class IV - Ca2+ channel blocker
    • Adenosine
    • Digitalis
  10. What are the 3 direct drug mechanisms that increase myocardial contractility?
    • Inhibits Na-K ATPase Pump (Digoxin)
    • Blocks B-Blockers (B-agonists)
    • Inhibits PDE3 which converts cAMP --> AMP
  11. How do B-receptor blockades have a therapeutic effect in CHF?
    Peripheral vasoconstriction and by impairing sodium excretion by the kidneys
  12. What are the B-blockers used to treat CHF?
    • Metoprolol - B-1 Blocker
    • Bisoprolol - B-1 Blocker
    • Carvedilol - α-1 receptor blockade
  13. What are the drugs/ drug targets in the renin-angiotensin-aldosterone system in the tx of CHF?
    • B1 receptor antagonists
    • ACE inhibitors
    • AT1 receptor antagonists
  14. Using Frank-Starling diagrams, what are the drug tx options for CHF?
    • Diuretics
    • Nitrates
    • Inotropic drugs
    • ACE-inhibitor
    • ARB
  15. What are the 2 goals for Heart Failure and how do you do it?
    • ↓ Pulmonary Congestion - ↓ PRELOAD
    • ↑ CO - ↓ SVR (AFTERLOAD), ↑ Contractility, ↑ HR
  16. What are the 3 ways to ↑ CO?
    • ↓ SVR (AFTERLOAD)
    • ↑ Contractility
    • ↑ HR
  17. How do you ↓ Pulmonary Congestion?
    ↓ PRELOAD
  18. What are the effects of Beta- Agonists?
    • ↑ Contractility (+ inotropy)
    • ↑ Relaxation Rate (+ lusitropy)
    • ↑ HR (+ chronotropy)
    • ↑ Conduction Velocity (+ dromotropy)
    • Smooth muscle relaxation (vasodilation)
    • Bronchodilation
    • Hepatic glycogenolysis
    • Pancreatic release of glucagon
    • Renin release by kidneys
  19. Where is the PDE isoenxyme found?
    • Myocardium on LV
    • Peripheral arterioles
  20. What are PDE-3 inhibitors?
    • Inotropic
    • Vasodilators
  21. What are 2 PDE-3 drugs that have IV constant infusion?
    • Milrinone
    • Inamrinone
  22. Which drug will block renin release?
    B-Blockers
  23. Which drug will inhibit Angiotensin I production?
    Direct renin inhibitor
  24. Which drug will inhibit angiotensin II production?
    ACE-inhibitor
  25. Which drug will inhibit AT-1 receptor stimulation?
    ARB
  26. Which drug will inhibit action of aldosterone on kidney?
    Aldosterone antagonist (spironolactone)
  27. What drugs will decrease preload?
    • Diuretics (Loop)
    • Nitrates (venodilators)

What would you like to do?

Home > Flashcards > Print Preview